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Pronunciation |
|
(sul
KON a
zole) |
|
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U.S. Brand
Names |
|
Exelderm®
Topical |
|
|
Generic
Available |
|
No |
|
|
Synonyms |
|
Sulconazole Nitrate |
|
|
Pharmacological Index |
|
Antifungal Agent, Topical |
|
|
Use |
|
Treatment of superficial fungal infections of the skin, including tinea
cruris (jock itch), tinea corporis (ringworm), tinea versicolor, and possibly
tinea pedis (athlete's foot - cream only) |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
Known hypersensitivity to sulconazole |
|
|
Warnings/Precautions |
|
Use with caution in nursing mothers; for external use
only |
|
|
Adverse
Reactions |
|
1% to 10%:
Local: Burning, stinging, redness |
|
|
Drug
Interactions |
|
No data reported |
|
|
Mechanism of
Action |
|
Substituted imidazole derivative which inhibits metabolic reactions necessary
for the synthesis of ergosterol, an essential membrane component. The end result
is usually fungistatic; however, sulconazole may act as a fungicide in
Candida albicans and parapsilosis during certain growth
phases. |
|
|
Pharmacodynamics/Kinetics |
|
Absorption: Topical: About 8.7% absorbed percutaneously
Elimination: Mostly in urine |
|
|
Usual Dosage |
|
Adults: Topical: Apply a small amount to the affected area and gently massage
once or twice daily for 3 weeks (tinea cruris, tinea corporis, tinea versicolor)
to 4 weeks (tinea pedis). |
|
|
Mental Health: Effects
on Mental Status |
|
None reported |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
For external use only; avoid contact with eyes; if burning or irritation
develops, notify physician |
|
|
Nursing
Implications |
|
For external use only; avoid contact with eyes; if burning or irritation
develops, notify physician |
|
|
Dosage Forms |
|
Cream, as nitrate: 1% (15 g, 30 g, 60 g)
Solution, as nitrate, topical: 1% (30 mL)
|
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