Genitourinary Irrigant; Laxative, Miscellaneous
Genitourinary irrigant in transurethral prostatic resection or other
transurethral resection or other transurethral surgical procedures; diuretic;
humectant; sweetening agent; hyperosmotic laxative; facilitate the passage of
sodium polystyrene sulfonate through the intestinal tract
Use with caution in patients with severe cardiopulmonary or renal impairment
and in patients unable to metabolize sorbitol
1% to 10%:
Endocrine & metabolic: Fluid and electrolyte losses, lactic acidosis
Gastrointestinal: Diarrhea, nausea, vomiting, abdominal discomfort,
Symptoms of overdose include nausea, diarrhea, fluid and electrolyte loss
Treatment is supportive to ensure fluid and electrolyte balance
Protect from freezing; avoid storage in temperatures
A polyalcoholic sugar with osmotic cathartic actions
Onset of action: About 0.25-1 hour
Absorption: Oral, rectal: Poor
Metabolism: Mainly in the liver to fructose
Hyperosmotic laxative (as single dose, at infrequent intervals):
Oral: 2 mL/kg (as 70% solution)
Rectal enema: 30-60 mL as 25% to 30% solution
Children >12 years and Adults:
Oral: 30-150 mL (as 70% solution)
Rectal enema: 120 mL as 25% to 30% solution
Adjunct to sodium polystyrene sulfonate: 15 mL as 70% solution orally until
diarrhea occurs (10-20 mL/2 hours) or 20-100 mL as an oral vehicle for the
sodium polystyrene sulfonate resin
When administered with charcoal:
Children: 4.3 mL/kg of 35% sorbitol with 1 g/kg of activated charcoal
Adults: 4.3 mL/kg of 70% sorbitol with 1 g/kg of activated charcoal every 4
hours until first stool containing charcoal is passed
Topical: 3% to 3.3% as transurethral surgical procedure irrigation
|Mental Health: Effects
on Mental Status|
Effects on Psychiatric
|Dental Health: Local
No information available to require special precautions
Effects on Dental Treatment|
No effects or complications reported
Cathartic: Use of cathartics on a regular basis will have adverse effects.
Increased exercise, increased fluid intake, or increased dietary fruit and fiber
may be effective in preventing and resolving constipation. Breast-feeding
precautions: Consult prescriber if breast-feeding.
Do not use unless solution is clear
Solution, genitourinary irrigation: 3% (1500 mL, 3000 mL); 3.3% (2000 mL)
Brown AM and Masson E,
"Hidden Sorbitol in Proprietary Medicines _ A Cause for Concern?" Pharm
J, 1990, 245:211.
Charney EB and Bodurtha JN,
"Intractable Diarrhea Associated With the Use of Sorbitol," J Pediatr,
Gazda-Smith E and Synhavsky A,
"Hypernatremia Following Treatment of Theophylline Toxicity With Activated Charcoal and Sorbitol,"
Arch Intern Med, 1990, 150(3):689, 692.
James LP, Nichols MH, and King WD,
"A Comparison of Cathartics in Pediatric Ingestions," Pediatrics, 1995,
96(2 Pt 1):235-8.
Kumar A, Weatherly MR, and Beaman DC,
"Sweeteners, Flavorings, and Dyes in Antibiotic Preparations,"
Pediatrics, 1991, 87(3):352-60.
Lederle FA, Busch DL, Mattox KM, et al,
"Cost-Effective Treatment of Constipation in the Elderly: A Randomized Double-Blend Comparison of Sorbitol and Lactulose,"
Am J Med, 1990, 89(5):597-601.
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