Yes

Salicylate

Treatment of minor pain or fever; arthritis

C

1% to 10%:

Gastrointestinal: Nausea, vomiting, GI distress, GI ulcers, GI bleeding

Hematologic: Platelet inhibition

Hepatic: Hepatotoxicity

Respiratory: Bronchospasm/wheezing

Ammonium chloride, vitamin C (high dose), methionine, antacids, urinary alkalinizers, carbonic anhydrase inhibitors, corticosteroids, nizatidine, alcohol, ACE inhibitors, beta-blockers, loop diuretics, methotrexate, probenecid, sulfinpyrazine, spironolactone, sulfonylureas

Inhibits prostaglandin synthesis, acts on the hypothalamus heat-regulating center to reduce fever; decreases pain receptor sensitivity. Other proposed mechanisms of action for salicylate anti-inflammatory action are lysosomal stabilization, kinin and leukotriene production, alteration of chemotactic factors, and inhibition of neutrophil activation. This latter mechanism may be the most significant pharmacologic action to reduce inflammation.

Absorption: From the stomach and small intestine

Serum half-life, aspirin: 15-20 minutes; metabolic pathways are saturable such that salicylates half-life is dose-dependent ranging from 3 hours at lower doses (300-600 mg), 5-6 hours (after 1 g) and 15-30 hours with higher doses; in therapeutic anti-inflammatory doses, half-lives generally range from 6-12 hours

Adults: Oral: 325-650 mg every 4 hours

No information available to require special precautions

No effects or complications reported

Watch for any signs of bleeding (stool); take with food to minimize GI distress; report ringing in ears, persistent GI pain to physician or pharmacist

Sodium content of 1 g: 6.25 mEq; less effective than an equal dose of aspirin in reducing pain or fever; patients hypersensitive to aspirin may be able to tolerate

Tablet, enteric coated: 325 mg, 650 mg