| Pronunciation |
 (SIN
ka
lide) |
 |
| U.S. Brand Names |
| Kinevac® |
|
| Generic Available |
|
No |
|
| Synonyms |
| C8-CCK; OP-CCK |
|
| Pharmacological Index |
|
Diagnostic Agent |
|
| Use |
|
Postevacuation cholecystography; gallbladder bile sampling; stimulate pancreatic secretion for analysis |
|
| Pregnancy Risk Factor |
|
B |
|
| Adverse Reactions |
|
1% to 10%: Central nervous system: Dizziness Gastrointestinal: Nausea, abdominal pain, urge to defecate |
|
| Stability |
|
Reconstituted solution may be kept at room temperature for 24 hours |
|
| Mechanism of Action |
|
Stimulates contraction of the gallbladder and simultaneous relaxation of the sphincter of Oddi, inhibits gastric emptying, and increases intestinal motility. Graded doses have been shown to produce graded decreases in small intestinal transit time, thought to be mediated by acetylcholine. |
|
| Pharmacodynamics/Kinetics |
|
Onset of action: Contraction of the gallbladder occurs within 5-15 minutes Duration: ~1 hour |
|
| Usual Dosage |
|
Adults: I.V.: Pancreatic function: 0.02 mcg/kg over 30 minutes administered after secretin |
|
| Administration |
|
I.V. infusion: Dilute to 30 mL with 0.9% NaCl I.V. push: Administer over 30-60 seconds |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Dosage Forms |
|
Injection: 5 mcg |
|
|
|
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