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Pronunciation |
|
(SEE
kre
tin) |
|
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U.S. Brand
Names |
|
Secretin-Ferring Powder |
|
|
Generic
Available |
|
No |
|
|
Pharmacological Index |
|
Diagnostic Agent |
|
|
Use |
|
Diagnosis of Zollinger-Ellison syndrome, chronic pancreatic dysfunction, and
some hepatobiliary diseases such as obstructive jaundice resulting from cancer
or stones in the biliary tract |
|
|
Pregnancy Risk
Factor |
|
Not established |
|
|
Adverse
Reactions |
|
<1%:
Miscellaneous: Hypersensitivity reactions |
|
|
Stability |
|
Unstable; should be used immediately after reconstitution, store in freezer
(-20°C) or store at 25°C for up to 3
weeks |
|
|
Mechanism of
Action |
|
Hormone normally secreted by duodenal mucosa and upper jejunal mucosa which
increases the volume and bicarbonate content of pancreatic juice; stimulates the
flow of hepatic bile with a high bicarbonate concentration, stimulates gastrin
release in patients with Zollinger-Ellison syndrome |
|
|
Pharmacodynamics/Kinetics |
|
Inactivated by proteolytic enzymes if administered orally
Peak output of pancreatic secretions: Within 30 minutes
Duration of action: At least 2 hours |
|
|
Usual Dosage |
|
Potency of secretin is expressed in terms of clinical units (CU). I.V.:
Zollinger-Ellison: 2 CU/kg slow I.V. injection over 1 minute
|
|
|
Administration |
|
Reconstitute with 7.5 mL of normal saline; do not shake; use
immediately by direct I.V. injection slowly over 1 minute |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Patients should fast 12-15 hours before test |
|
|
Nursing
Implications |
|
Patients should fast 12-15 hours before test; reconstitute with 7.5 mL of
normal saline; do not shake; use immediately by direct I.V. injection
slowly over 1 minute
Monitor duodenal fluid volume and bicarbonate content; serum gastrin
(Zollinger-Ellison syndrome) |
|
|
Dosage Forms |
|
Powder for injection: 75 units (10
mL) |
|
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