| Pronunciation |
 (sal
i SIL ik AS
id) |
 |
| U.S. Brand Names |
| Clear Away® Disc [OTC]; Compound W®[OTC]; Dr Scholl's® Disk [OTC]; Dr Scholl's® Wart Remover [OTC]; DuoFilm®[OTC]; DuoPlant® Gel [OTC]; Freezone® Solution [OTC]; Gordofilm® Liquid; Mediplast® Plaster [OTC]; Mosco® Liquid [OTC]; Occlusal®-HP Liquid; Off-Ezy® Wart Remover [OTC]; Panscol®[OTC]; Psor-a-set® Soap [OTC]; P&S® Shampoo [OTC]; Sal-Acid® Plaster [OTC]; Salactic® Film [OTC]; Sal-Plant® Gel [OTC]; Trans-Ver-Sal® AdultPatch [OTC]; Trans-Ver-Sal® PediaPatch [OTC]; Trans-Ver-Sal® PlantarPatch [OTC]; Wart-Off®[OTC] |
|
| Generic Available |
|
Yes |
|
| Pharmacological Index |
|
Keratolytic Agent |
|
| Use |
|
Topically for its keratolytic effect in controlling seborrheic dermatitis or psoriasis of body and scalp, dandruff, and other scaling dermatoses; also used to remove warts, corns, and calluses |
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| Pregnancy Risk Factor |
|
C |
|
| Adverse Reactions |
|
>10%: Local: Burning and irritation at site of exposure on normal tissue 1% to 10%: Central nervous system: Dizziness, mental confusion, headache Otic: Tinnitus Respiratory: Hyperventilation |
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| Drug Interactions |
|
No data reported |
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| Mechanism of Action |
|
Produces desquamation of hyperkeratotic epithelium via dissolution of the intercellular cement which causes the cornified tissue to swell, soften, macerate, and desquamate. Salicylic acid is keratolytic at concentrations of 3% to 6%; it becomes destructive to tissue at concentrations >6%. Concentrations of 6% to 60% are used to remove corns and warts and in the treatment of psoriasis and other hyperkeratotic disorders. |
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| Pharmacodynamics/Kinetics |
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Absorption: Absorbed percutaneously, but systemic toxicity is unlikely with normal use Time to peak serum concentration: Topical: Within 5 hours of application with occlusion |
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| Usual Dosage |
|
Lotion, cream, gel: Apply a thin layer to affected area once or twice daily Plaster: Cut to size that covers the corn or callus, apply and leave in place for 48 hours; do not exceed 5 applications over a 14-day period Solution: Apply a thin layer directly to wart using brush applicator once daily as directed for 1 week or until wart is removed |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Patient Information |
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When applying in concentrations of >10%, protect surrounding tissue with petrolatum; do not use on open skin, avoid contact with eyes, mouth, and other mucous membranes |
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| Nursing Implications |
|
For warts: Before applying product, soak area in warm water for 5 minutes; dry area thoroughly, then apply medication Monitor for signs and symptoms of salicylate toxicity: nausea, vomiting, dizziness, tinnitus, loss of hearing, lethargy, diarrhea, psychic disturbances |
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| Dosage Forms |
|
Cream: 2% (30 g) Disk: 40% Gel: 5% (60 g); 6% (30 g); 17% (7.5 g) Liquid: 13.6% (9.3 mL); 17% (9.3 mL, 13.5 mL, 15 mL); 16.7% (15 mL) Lotion: 3% (120 mL) Ointment: 3% (90 g) Patch, transdermal: 15% (20 mm); 40% (20 mm) Plaster: 40% Soap: 2% (97.5 g) Strip: 40% |
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