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Rubella and Mumps Vaccines, Combined
Pronunciation
U.S. Brand Names
Generic Available
Pharmacological Index
Use
Pregnancy Risk Factor
Pregnancy/Breast-Feeding Implications
Contraindications
Warnings/Precautions
Adverse Reactions
Drug Interactions
Stability
Usual Dosage
Administration
Test Interactions
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms
References

Pronunciation
(rue BEL a & mumpz vak SEENS, kom BINED)

U.S. Brand Names
Biavax® II

Generic Available

No


Pharmacological Index

Vaccine


Use

Promote active immunity to rubella and mumps by inducing production of antibodies


Pregnancy Risk Factor

C


Pregnancy/Breast-Feeding Implications

Women who are pregnant when vaccinated or who become pregnant within 3 months of vaccination should be counseled on the theoretical risks to the fetus. The risk of rubella-associated malformations in these women is so small as to be negligible. MMR is the vaccine of choice if recipients are likely to be susceptible to measles or mumps as well as to rubella.


Contraindications

Known hypersensitivity to neomycin, eggs; children <1 year, pregnant women, primary immunodeficient patients, patients receiving immunosuppressant drugs except corticosteroids


Warnings/Precautions

Women planning on becoming pregnant in the next 3 months should not be vaccinated


Adverse Reactions

All serious adverse reactions must be reported to the U.S. Department of Health and Human Services (DHHS) Vaccine Adverse Event Reporting System (VAERS) 1-800-822-7967.

Dermatologic: Local tenderness and erythema, urticaria, rash

Neuromuscular & skeletal: Arthralgia

1% to 10%:

Central nervous system: Malaise, moderate fever, headache

Gastrointestinal: Sore throat

Miscellaneous: Lymphadenopathy

<1%: High fever (>103°F), encephalitis, polyneuropathy, erythema multiforme, optic neuritis, hypersensitivity, allergic reactions to the vaccine


Drug Interactions

Whole blood, interferon immune globulin, radiation therapy, and immunosuppressive drugs (eg, corticosteroids) may result in insufficient response to immunization; may temporarily depress tuberculin skin test sensitivity and reduce the seroconversion. DTP, OPV, MMR, Hib, and hepatitis B may be given concurrently; other virus vaccine administration should be separated by greater than or equal to 1 month.


Stability

Refrigerate, discard unused portion within 8 hours, protect from light


Usual Dosage

Children >12 months (preferably at 15 months) and Adults: 1 vial (0.5 mL) in outer aspect of the upper arm; children vaccinated before 12 months of age should be revaccinated


Administration

Administer S.C. only


Test Interactions

Temporary suppression of TB skin test


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

Patient may experience burning or stinging at the injection site; joint pain usually occurs 1-10 weeks after vaccination and persists 1-3 days


Nursing Implications

Children immunized before 12 months of age should be reimmunized


Dosage Forms

Injection (mixture of 2 viruses):

2. Jeryl Lynn (B level) mumps strain grown cell cultures of chick embryo


References

Gardner P and Schaffner W, "Immunization of Adults," N Engl J Med, 1993, 328(17):1252-8.


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