No

Immune Globulin

Prevention of isoimmunization in Rh-negative individuals exposed to Rh-positive blood during delivery of an Rh-positive infant, as a result of an abortion, following amniocentesis or abdominal trauma, or following a transfusion accident; prevention of hemolytic disease of the newborn if there is a subsequent pregnancy with an Rh-positive fetus

C

Rh_o(D)-positive patient; known hypersensitivity to immune globulins or to thimerosal; transfusion of Rh_o(D)-positive blood in previous 3 months; prior sensitization to Rh_o(D)

Use with caution in patients with thrombocytopenia or bleeding disorders, patients with IgA deficiency; do not inject I.V.; do not administer to neonates

<1%: Lethargy, splenomegaly, elevated bilirubin, pain at the injection site, myalgia, temperature elevation

Reconstituted solution should be refrigerated and will remain stable for 30 days; solutions that have been frozen should be discarded

Suppresses the immune response and antibody formation of Rh-negative individuals to Rh-positive red blood cells

Distribution: Appears in breast milk; however, not absorbed by the nursing infant

Half-life: 23-26 days

Adults (administered I.M. to mothers not to infant) I.M.:

Postpartum prophylaxis: 300 mcg within 72 hours of delivery

Antepartum prophylaxis: 300 mcg at approximately 26-28 weeks gestation; followed by 300 mcg within 72 hours of delivery if infant is Rh-positive

Following miscarriage, abortion, or termination of ectopic pregnancy at up to 13 weeks of gestation: 50 mcg ideally within 3 hours, but may be given up to 72 hours after; if pregnancy has been terminated at 13 or more weeks of gestation, administer 300 mcg

Give I.M. in deltoid muscle; do not give I.V.; the total volume can be given in divided doses at different sites at one time or may be divided and given at intervals, provided the total dosage is given within 72 hours of the fetomaternal hemorrhage or transfusion.

No information available to require special precautions

No effects or complications reported

Acetaminophen may be taken to ease minor discomfort after vaccination

Injection: Each package contains one single dose 300 mcg of Rh_o (D) immune globulin

Injection, microdose: Each package contains one single dose of microdose, 50 mcg of Rh_o (D) immune globulin

Hartwell EA, "Use of Rh Immune Globulin: ASCP Practice Parameter. American Society of Clinical Pathologists," Am J Clin Pathol, 1998, 110(3):281-92.

"Rh_o(D) Immune Globulin I.V. for Prevention of Rh Isoimmunization and for Treatment of ITP," Med Lett Drugs Ther, 1996, 38(966):6-8.

Simpson KN, Coughlin CM, Eron J, et al, "Idiopathic Thrombocytopenia Purpura: Treatment Patterns and an Analysis of Cost Associated With Intravenous Immunoglobulin and Anti-D Therapy," Semin Hematol, 1998, 35(1 Suppl 1):58-64.

Ware RE and Zimmerman SA, "Anti-D: Mechanisms of Action," Semin Hematol, 1998, 35(1 Suppl 1):14-22.