| Pronunciation |
 (SIL
i yum) |
 |
| U.S. Brand Names |
| Effer-Syllium®[OTC]; Fiberall® Powder [OTC]; Fiberall® Wafer [OTC]; Hydrocil®[OTC]; Konsyl®[OTC]; Konsyl-D®[OTC]; Metamucil®[OTC]; Metamucil® Instant Mix [OTC]; Modane® Bulk [OTC]; Perdiem® Plain [OTC]; Reguloid®[OTC]; Serutan®[OTC]; Syllact®[OTC]; V-Lax®[OTC] |
|
| Generic Available |
|
Yes |
|
| Canadian Brand Names |
| Fibrepur®; Novo-Mucilax; Prodiem® Plain |
|
| Synonyms |
| Plantago Seed; Plantain Seed; Psyllium Hydrophilic Mucilloid |
|
| Pharmacological Index |
|
Laxative, Bulk-Producing |
|
| Use |
|
Treatment of chronic atonic or spastic constipation and of constipation associated with rectal disorders; management of irritable bowel syndrome |
|
| Pregnancy Risk Factor |
|
B |
|
| Contraindications |
|
Fecal impaction, GI obstruction, hypersensitivity to psyllium or any component |
|
| Warnings/Precautions |
|
May contain aspartame which is metabolized in the GI tract to phenylalanine which is contraindicated in individuals with phenylketonuria; use with caution in patients with esophageal strictures, ulcers, stenosis, or intestinal adhesions; elderly may have insufficient fluid intake which may predispose them to fecal impaction and bowel obstruction. |
|
| Adverse Reactions |
|
1% to 10%: Respiratory: Bronchospasm Miscellaneous: Anaphylaxis upon inhalation in susceptible individuals, rhinoconjunctivitis |
|
| Overdosage/Toxicology |
|
Symptoms of overdose include abdominal pain, diarrhea, constipation |
|
| Drug Interactions |
|
Decreased effect of warfarin, digitalis, potassium-sparing diuretics, salicylates, tetracyclines, nitrofurantoin |
|
| Mechanism of Action |
|
Adsorbs water in the intestine to form a viscous liquid which promotes peristalsis and reduces transit time |
|
| Pharmacodynamics/Kinetics |
|
Onset of action: 12-24 hours, but full effect may take 2-3 days Peak effect: May take 2-3 days Absorption: Oral: Generally not absorbed following administration, small amounts of grain extracts present in the preparation have been reportedly absorbed following colonic hydrolysis |
|
| Usual Dosage |
|
Oral (administer at least 3 hours before or after drugs): Adults: 1-2 rounded teaspoonfuls or 1-2 packets or 1-2 wafers in 8 oz glass of liquid 1-3 times/day |
|
| Dietary Considerations |
|
Should be administered with large amount of fluids |
|
| Mental Health: Effects on Mental Status |
|
None reported |
|
| Mental Health: Effects on Psychiatric Treatment |
|
None reported |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
Mix in large (8 oz or more) glass of water or juice and drink immediately. Mix carefully; do not inhale powder. Report unresolved or persistent constipation, watery diarrhea, or respiratory difficulty. Pregnancy precautions: Inform prescriber if you are or intend to be pregnant. |
|
| Nursing Implications |
|
Inhalation of psyllium dust may cause sensitivity to psyllium (runny nose, watery eyes, wheezing) |
|
| Dosage Forms |
|
Granules: 4.03 g per rounded teaspoon (100 g, 250 g); 2.5 g per rounded teaspoon Powder: Psyllium 50% and dextrose 50% (6.5 g, 325 g, 420 g, 480 g, 500 g) Powder: Effervescent: 3 g/dose (270 g, 480 g); 3.4 g/dose (single-dose packets) Psyllium hydrophilic: 3.4 g per rounded teaspoon (210 g, 300 g, 420 g, 630 g) Squares, chewable: 1.7 g, 3.4 g Wafers: 3.4 g |
|
|
|
Copyright © 1978-2000 Lexi-Comp Inc. All Rights Reserved
