Immediate release: Yes

Antihypertensive Agent, Combination

Management of hypertension

C

Dose is individualized

Combination therapy for the treatment of hypertension should be individualized for each patient. Potential advantages for propranolol and hydrochlorothiazide combination therapy may include improved compliance and synergistic reductions in blood pressure with an accompanied reduction in side effects.

Use with caution; epinephrine has interacted with nonselective beta-blockers to result in initial hypertensive episode followed by bradycardia

Noncardioselective beta-blockers (ie, propranolol, nadolol) enhance the pressor response to epinephrine, resulting in hypertension and bradycardia. Many nonsteroidal anti-inflammatory drugs such as ibuprofen and indomethacin can reduce the hypotensive effect of beta-blockers after 3 or more weeks of therapy with the NSAID. Short-term NSAID use (ie, 3 days) requires no special precautions in patients taking beta-blockers.

See individual agents. Pregnancy precautions: Inform prescriber if you are or intend to get pregnant.

Capsule, long-acting (Inderide® LA):

80/50 Propranolol hydrochloride 80 mg and hydrochlorothiazide 50 mg

120/50 Propranolol hydrochloride 120 mg and hydrochlorothiazide 50 mg

160/50 Propranolol hydrochloride 160 mg and hydrochlorothiazide 50 mg

Tablet (Inderide®):

40/25 Propranolol hydrochloride 40 mg and hydrochlorothiazide 25 mg

80/25 Propranolol hydrochloride 80 mg and hydrochlorothiazide 25 mg