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Proparacaine and Fluorescein
Pronunciation
U.S. Brand Names
Generic Available
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Drug Interactions
Stability
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(proe PAR a kane & FLURE e seen)

U.S. Brand Names
Fluoracaine® Ophthalmic

Generic Available

Yes


Pharmacological Index

Diagnostic Agent; Local Anesthetic


Use

Anesthesia for tonometry, gonioscopy; suture removal from cornea; removal of corneal foreign body; cataract extraction, glaucoma surgery


Pregnancy Risk Factor

C


Contraindications

Known hypersensitivity to proparacaine or fluorescein or any component or ester-type local anesthetics


Warnings/Precautions

Use with caution in patients with cardiac disease, hyperthyroidism; for topical ophthalmic use only; prolonged use not recommended


Adverse Reactions

1% to 10%: Local: Burning, stinging of eye

<1%: Allergic contact dermatitis, irritation, sensitization, erosion of the corneal epithelium, conjunctival congestion and hemorrhage, keratitis, iritis, corneal opacification


Drug Interactions

No data reported


Stability

Store in tight, light-resistant containers


Mechanism of Action

Prevents initiation and transmission of impulse at the nerve cell membrane by decreasing ion permeability through stabilizing


Pharmacodynamics/Kinetics

Onset of action: Within 20 seconds of instillation

Duration: 15-20 minutes


Usual Dosage

Ophthalmic surgery: Children and Adults: Instill 1 drop in each eye every 5-10 minutes for 5-7 doses

Tonometry, gonioscopy, suture removal: Adults: Instill 1-2 drops in each eye just prior to procedure


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

May slow wound healing; use sparingly, avoid touching or rubbing the eye until anesthesia has worn off


Nursing Implications

Do not use if discolored; protect eye from irritating chemicals, foreign bodies, and blink reflex; use eye patch if necessary


Dosage Forms

Solution: Proparacaine hydrochloride 0.5% and fluorescein sodium 0.25% (2 mL, 5 mL)


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