Yes: 15 mg tablet

Anticholinergic Agent

Adjunctive treatment of peptic ulcer, irritable bowel syndrome, pancreatitis, ureteral and urinary bladder spasm; reduce duodenal motility during diagnostic radiologic procedures

C

Narrow-angle glaucoma, known hypersensitivity to propantheline; ulcerative colitis; toxic megacolon; obstructive disease of the GI or urinary tract

Use with caution in patients with hyperthyroidism, hepatic, cardiac, or renal disease, hypertension, GI infections, or other endocrine diseases.

>10%:

Dermatologic: Dry skin

Gastrointestinal: Constipation, dry mouth and throat

Respiratory: Dry nose

Miscellaneous: Diaphoresis (decreased)

1% to 10%: Gastrointestinal: Dysphagia

Symptoms of overdose include CNS disturbances, flushing, respiratory failure, paralysis, coma, urinary retention, and hyperthermia. For anticholinergic overdose with severe life-threatening symptoms, physostigmine 1-2 mg S.C. or I.V. slowly, may be given to reverse these effects.

Decreased effect with antacids (decreased absorption); decreased effect of sustained release dosage forms (decreased absorption)

Increased effect/toxicity with anticholinergics, disopyramide, narcotic analgesics, bretylium, type I antiarrhythmics, antihistamines, phenothiazines, TCAs, corticosteroids (increased IOP), CNS depressants (sedation), adenosine, amiodarone, beta-blockers, amoxapine

Competitively blocks the action of acetylcholine at postganglionic parasympathetic receptor sites

Onset of effect: Oral: Within 30-45 minutes

Duration: 4-6 hours

Serum half-life: 1.6 hours (average)

Oral:

Children: 1-2 mg/kg/day in 3-4 divided doses

Adults: 15 mg 3 times/day before meals or food and 30 mg at bedtime

Elderly: 7.5 mg 3 times/day before meals and at bedtime

Antispasmodic:

Children: 2-3 mg/kg/day in divided doses every 4-6 hours and at bedtime

Adults: 15 mg 3 times/day before meals or food and 30 mg at bedtime

Should be taken 30 minutes before meals so that the drug's peak effect occurs at the proper time

May cause drowsiness, confusion, amnesia, nervousness, or insomnia

Concurrent use with psychotropics may produce additive sedation or anticholinergic side effects (dry mouth)

No information available to require special precautions

Significant xerostomia in >10% of patients - (therapeutic effect)

Take as directed before meals; do not increase dose and do not discontinue without consulting prescriber. Void before taking medication. You may experience constipation (increased dietary fruit, fluids, fiber, and exercise may help). Report chest pain or rapid heartbeat, or excessive and persistent anticholinergic effects (blurred vision, headache, flushing, tachycardia, nervousness, constipation, dizziness, insomnia, mental confusion or excitement, dry mouth, altered taste perception, dysphagia, palpitations, bradycardia, urinary hesitancy or retention, impotence, decreased sweating). Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

Monitor anticholinergic effects, orthostatic changes

Tablet, as bromide: 7.5 mg, 15 mg