|
Pronunciation |
|
(PROE
byoo
kole) |
|
|
Generic
Available |
|
No |
|
|
Synonyms |
|
Biphenabid |
|
|
Pharmacological Index |
|
Antilipemic Agent (Miscellaneous) |
|
|
Use |
|
Adjunct to dietary therapy to decrease elevated serum total and LDL
cholesterol concentrations in primary hypercholesterolemia |
|
|
Pregnancy Risk
Factor |
|
B |
|
|
Contraindications |
|
Ventricular arrhythmias; hypersensitivity to probucol or any
component |
|
|
Adverse
Reactions |
|
>10%:
Cardiovascular: Q-T prolongation, serious arrhythmias
Gastrointestinal: Bloating, diarrhea, stomach pain, nausea, vomiting
1% to 10%: Central nervous system: Dizziness, headache, numbness of
extremities |
|
|
Drug
Interactions |
|
Increased toxicity: Drugs that prolong the Q-T interval (eg, tricyclic
antidepressants, some antiarrhythmic agents, phenothiazines) or with drugs that
affect the atrial rate (eg, beta-adrenergic blocking agents) or that can cause
A-V block (eg, digoxin) |
|
|
Mechanism of
Action |
|
Increases the fecal loss of bile acid-bound low density lipoprotein
cholesterol, decreases the synthesis of cholesterol and inhibits enteral
cholesterol absorption |
|
|
Usual Dosage |
|
Oral:
<27 kg: 250 mg twice daily with meals
>27 kg: 500 mg twice daily with meals
Adults: 500 mg twice daily administered with the morning and evening meals
|
|
|
Mental Health: Effects
on Mental Status |
|
May cause dizziness |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
Concurrent use with phenothiazines, TCAs, or beta-blockers may produce AV
block |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Take with meals; notify physician if diarrhea, abdominal pain, nausea, or
vomiting becomes severe or persist |
|
|
Dosage Forms |
|
Tablet: 250 mg, 500 mg |
|
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