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Probucol
Pronunciation
Generic Available
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Adverse Reactions
Drug Interactions
Mechanism of Action
Usual Dosage
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Dosage Forms

Pronunciation
(PROE byoo kole)

Generic Available

No


Synonyms
Biphenabid

Pharmacological Index

Antilipemic Agent (Miscellaneous)


Use

Adjunct to dietary therapy to decrease elevated serum total and LDL cholesterol concentrations in primary hypercholesterolemia


Pregnancy Risk Factor

B


Contraindications

Ventricular arrhythmias; hypersensitivity to probucol or any component


Adverse Reactions

>10%:

Cardiovascular: Q-T prolongation, serious arrhythmias

Gastrointestinal: Bloating, diarrhea, stomach pain, nausea, vomiting

1% to 10%: Central nervous system: Dizziness, headache, numbness of extremities


Drug Interactions

Increased toxicity: Drugs that prolong the Q-T interval (eg, tricyclic antidepressants, some antiarrhythmic agents, phenothiazines) or with drugs that affect the atrial rate (eg, beta-adrenergic blocking agents) or that can cause A-V block (eg, digoxin)


Mechanism of Action

Increases the fecal loss of bile acid-bound low density lipoprotein cholesterol, decreases the synthesis of cholesterol and inhibits enteral cholesterol absorption


Usual Dosage

Oral:

<27 kg: 250 mg twice daily with meals

>27 kg: 500 mg twice daily with meals

Adults: 500 mg twice daily administered with the morning and evening meals


Mental Health: Effects on Mental Status

May cause dizziness


Mental Health: Effects on Psychiatric Treatment

Concurrent use with phenothiazines, TCAs, or beta-blockers may produce AV block


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

Take with meals; notify physician if diarrhea, abdominal pain, nausea, or vomiting becomes severe or persist


Dosage Forms

Tablet: 250 mg, 500 mg


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