|
Pronunciation |
|
(pra
MOKS
een) |
|
|
U.S. Brand
Names |
|
Anusol® Ointment [OTC]; Fleet®
Pain Relief [OTC]; Itch-X®[OTC]; Phicon®[OTC];
PrameGel®[OTC]; Prax®[OTC]; ProctoFoam® NS [OTC];
Tronolane®[OTC] |
|
|
Generic
Available |
|
No |
|
|
Synonyms |
|
Pramoxine Hydrochloride |
|
|
Pharmacological Index |
|
Local Anesthetic |
|
|
Use |
|
Temporary relief of pain and itching associated with anogenital pruritus or
irritation; dermatosis, minor burns, or hemorrhoids |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Adverse
Reactions |
|
1% to 10%:
Dermatologic: Angioedema
Local: Contact dermatitis, burning, stinging
<1%:
Cardiovascular: Edema
Dermatologic: Urticaria
Genitourinary: Urethritis
Hematologic: Methemoglobinemia in infants
Local: Tenderness |
|
|
Drug
Interactions |
|
No data reported |
|
|
Mechanism of
Action |
|
Pramoxine, like other anesthetics, decreases the neuronal membrane's
permeability to sodium ions; both initiation and conduction of nerve impulses
are blocked, thus depolarization of the neuron is inhibited |
|
|
Pharmacodynamics/Kinetics |
|
Onset of therapeutic effect: Within 2-5 minutes
Peak effect: 3-5 minutes
Duration: May last for several days |
|
|
Usual Dosage |
|
Adults: Topical: Apply as directed, usually every 3-4 hours to affected area
(maximum adult dose: 200 mg) |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Discontinue if rash appears or if condition worsens or does not improve in
3-4 days |
|
|
Nursing
Implications |
|
Apply sparingly, use the minimal effective dose |
|
|
Dosage Forms |
|
Pramoxine hydrochloride:
Cream:
Prax®: 1% (30 g, 113.4 g, 454 g)
Tronolane®: 1% (30 g, 60 g)
Tronothane® HCl: 1% (28.4 g)
Gel, topical:
Itch-X®: 1% (35.4 g)
PrameGel®: 1% (118 g)
Lotion (Prax®): 1% (15 mL, 120 mL, 240 mL)
Ointment (Anusol®): 1% (30 g)
Pads (Fleet® Pain Relief): 1% (100s)
Spray (Itch-X®): 1% (60 mL)
|
|
Copyright © 1978-2000 Lexi-Comp Inc. All Rights Reserved
|