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Povidone-Iodine
Pronunciation
U.S. Brand Names
Generic Available
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms
References

Pronunciation
(POE vi done EYE oh dyne)

U.S. Brand Names
ACU-dyne®[OTC]; Aerodine®[OTC]; Betadine®[OTC]; Betadine® 5% Sterile Ophthalmic Prep Solution; Betagan®[OTC]; Biodine [OTC]; Efodine®[OTC]; Iodex®[OTC]; Iodex-p®[OTC]; Mallisol®[OTC]; Massengill® Medicated Douche w/Cepticin [OTC]; Minidyne®[OTC]; Operand®[OTC]; Polydine®[OTC]; Summer's Eve® Medicated Douche [OTC]; Yeast-Gard® Medicated Douche

Generic Available

Yes


Pharmacological Index

Antibiotic, Topical; Topical Skin Product


Use

External antiseptic with broad microbicidal spectrum against bacteria, fungi, viruses, protozoa, and yeasts


Pregnancy Risk Factor

D


Contraindications

Hypersensitivity to iodine


Warnings/Precautions

Highly toxic if ingested; sodium thiosulfate is the most effective chemical antidote; avoid contact with eyes


Adverse Reactions

1% to 10%:

Dermatologic: Rash, pruritus

Local: Local edema

<1%: Systemic absorption in extensive burns causing iododerma, metabolic acidosis, and renal impairment


Drug Interactions

No data reported


Mechanism of Action

Povidone-iodine is known to be a powerful broad spectrum germicidal agent effective against a wide range of bacteria, viruses, fungi, protozoa, and spores.


Pharmacodynamics/Kinetics

Absorption: In normal individuals, topical application results in very little systemic absorption; with vaginal administration, however, absorption is rapid and serum concentrations of total iodine and inorganic iodide are increased significantly


Usual Dosage

Shampoo: Apply 2 teaspoons to hair and scalp, lather and rinse; repeat application 2 times/week until improvement is noted, then shampoo weekly

Topical: Apply as needed for treatment and prevention of susceptible microbial infections


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

Do not swallow; avoid contact with eyes


Nursing Implications

Avoid contact with eyes


Dosage Forms

Aerosol: 5% (88.7 mL, 90 mL)

Antiseptic gauze pads: 10% (3" x 9")

Cleanser:

Skin: 7.5% (30 mL, 118 mL)

Skin, foam: 7.5% (170 g)

Topical: 60 mL, 240 mL

Concentrate, whirlpool: 3,840 mL

Cream: 5% (14 g)

Douche (10%): 0.5 oz/packet (6 packets/box), 240 mL

Foam, topical (10%): 250 g

Gel:

Lubricating: 5% (5 g)

Vaginal (10%): 18 g, 90 g

Liquid: 473 mL

Mouthwash (0.5%): 177 mL

Ointment, topical: 10% (0.94 g, 3.8 g, 28 g, 30 g, 454 g); 1 g, 1.2 g, 2.7 g packets

Perineal wash concentrate: 1% (240 mL); 10% (236 mL)

Scrub, surgical: 7.5% (15 mL, 473 mL, 946 mL)

Shampoo: 7.5% (118 mL)

Solution:

Ophthalmic sterile prep: 5% (50 mL)

Prep: 30 mL, 60 mL, 240 mL, 473 mL, 1000 mL, 4000 mL

Swab aid: 1%

Swabsticks: 4"

Topical: 10% (15 mL, 30 mL, 120 mL, 237 mL, 473 mL, 480 mL, 1000 mL, 4000 mL)

Suppositories, vaginal: 10%


References

Apt L, Isenberg SJ, Yoshimori R, et al, "The Effect of Povidone-Iodine Solution at the Conclusion of Ophthalmic Surgery," Am J Ophthalmol, 1995, 119(6):701-5.

Dela Cruz F, Brown DH, Leikin JB, et al, "Iodine Absorption After Topical Administration," West J Med, 1987, 146(1):43-5.

Klein I and Levey GS, "Iodide Excess and Thyroid Function," Ann Intern Med, 1983, 98(3):406-7.


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