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Potassium Gluconate
Pronunciation
U.S. Brand Names
Generic Available
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Overdosage/Toxicology
Drug Interactions
Stability
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Administration
Monitoring Parameters
Test Interactions
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(poe TASS ee um GLOO coe nate)

U.S. Brand Names
Kaon®; K-G®

Generic Available

Yes


Pharmacological Index

Electrolyte Supplement, Oral


Use

Treatment or prevention of hypokalemia


Pregnancy Risk Factor

A


Contraindications

Severe renal impairment, untreated Addison's disease, heat cramps, hyperkalemia, severe tissue trauma; solid oral dosage forms are contraindicated in patients in whom there is a structural, pathological, and/or pharmacologic cause for delay or arrest in passage through the GI tract; an oral liquid potassium preparation should be used in patients with esophageal compression or delayed gastric emptying time


Warnings/Precautions

Use with caution in patients with cardiac disease, severe renal impairment, hyperkalemia; patients must be on a cardiac monitor during intermittent infusions


Adverse Reactions

>10%: Gastrointestinal: Diarrhea, nausea, stomach pain, flatulence, vomiting (oral)

1% to 10%:

Cardiovascular: Bradycardia

Endocrine & metabolic: Hyperkalemia

Neuromuscular & skeletal: Weakness

Respiratory: Dyspnea

<1%: Chest pain, mental confusion, alkalosis, throat pain, phlebitis, paresthesias, paralysis


Overdosage/Toxicology

Symptoms of overdose include muscle weakness, paralysis, peaked T waves, flattened P waves, prolongation of QRS complex, ventricular arrhythmias

Removal of potassium can be accomplished by various means; removal through the GI tract with Kayexalate® administration; by way of the kidney through diuresis, mineralocorticoid administration or increased sodium intake; by hemodialysis or peritoneal dialysis; or by shifting potassium back into the cells by insulin, glucose infusion, or sodium bicarbonate; calcium chloride reverses cardiac effects


Drug Interactions

Increased effect/levels with potassium-sparing diuretics, salt substitutes, ACE inhibitors; increased effect of digitalis


Stability

Store at room temperature, protect from freezing; use only clear solutions


Mechanism of Action

Potassium is the major cation of intracellular fluid and is essential for the conduction of nerve impulses in heart, brain, and skeletal muscle; contraction of cardiac, skeletal and smooth muscles; maintenance of normal renal function, acid-base balance, carbohydrate metabolism, and gastric secretion


Pharmacodynamics/Kinetics

Absorption: Absorbed well from upper GI tract

Distribution: Enters cells via active transport from extracellular fluid

Elimination: Largely by the kidneys, but also small amount via the skin and feces, with most intestinal potassium being reabsorbed


Usual Dosage

Oral (doses listed as mEq of potassium):

Children: 2-3 mEq/kg/day

Adults: 40-80 mEq/day

Prevention of hypokalemia during diuretic therapy:

Children: 1-2 mEq/kg/day in 1-2 divided doses

Adults: 16-24 mEq/day in 1-2 divided doses

Treatment of hypokalemia:

Children: 2-5 mEq/kg/day in 2-4 divided doses

Adults: 40-100 mEq/day in 2-4 divided doses


Administration

Liquid potassium preparation should be used in patients with esophageal compression or delayed gastric-emptying time


Monitoring Parameters

Serum potassium, chloride, glucose, pH, urine output (if indicated)


Test Interactions

ammonia (B)


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

Take with food, water, or fruit juice; swallow tablets whole; do not crush or chew


Nursing Implications

Do not administer liquid full strength, must be diluted in 2-6 parts of water or juice


Dosage Forms

Elixir: 20 mEq/15 mL

K-G®, Kaon®, Kaylixir®: 20 mEq/15 mL

Tablet:

Glu-K®: 2 mEq

Kaon®: 5 mEq


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