Yes

Antihistamine/Decongestant/Analgesic

Intermittent symptomatic treatment of nasal congestion in sinus or other frontal headache; allergic rhinitis, vasomotor rhinitis, coryza; facial pain and pressure of acute and chronic sinusitis

C

Oral:

Adults: 1 tablet every 12 hours (twice daily)

Use with caution since phenylpropanolamine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response

Acetaminophen: No effects or complications reported

Phenylpropanolamine: Up to 10% of patients could experience tachycardia, palpitations, and dry mouth; use vasoconstrictor with caution

Tablet: Phenyltoloxamine citrate 22 mg, phenylpropanolamine hydrochloride 25 mg, and acetaminophen 325 mg

Barker JD Jr, de Carle DJ, and Anuras S, "Chronic Excessive Acetaminophen Use in Liver Damage," Ann Intern Med, 1977, 87(3):299-301.

Dionne RA, Campbell RA, Cooper SA, et al, "Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine," J Clin Pharmacol, 1983, 23(1):37-43.

Licht H, Seeff LB, and Zimmerman HJ, "Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol," Ann Intern Med, 1980, 92(4):511.