No

Alpha₁ Blockers

Symptomatic management of pheochromocytoma; treatment of hypertensive crisis caused by sympathomimetic amines

C

Conditions in which a fall in blood pressure would be undesirable (eg, shock)

Use with caution in patients with renal impairment, cerebral, or coronary arteriosclerosis, can exacerbate symptoms of respiratory tract infections. Because of the risk of adverse effects, avoid the use of this medication in the elderly if possible.

>10%:

Cardiovascular: Postural hypotension, tachycardia, syncope

Ocular: Miosis

Respiratory: Nasal congestion

1% to 10%:

Cardiovascular: Shock

Central nervous system: Lethargy, headache, confusion, fatigue

Gastrointestinal: Vomiting, nausea, diarrhea, xerostomia

Genitourinary: Inhibition of ejaculation

Neuromuscular & skeletal: Weakness

Symptoms of overdose include hypotension, tachycardia, lethargy, dizziness, shock

Hypotension and shock should be treated with fluids and by placing the patient in the Trendelenburg position; only alpha-adrenergic pressors such as norepinephrine should be used; mixed agents such as epinephrine, may cause more hypotension

Alpha adrenergic agonists decrease the effect of phenoxybenzamine.

Beta-blockers may result in increased toxicity (hypotension, tachycardia).

Produces long-lasting noncompetitive alpha-adrenergic blockade of postganglionic synapses in exocrine glands and smooth muscle; relaxes urethra and increases opening of the bladder

Onset of action: Oral: Within 2 hours

Peak effect: Within 4-6 hours

Duration: Can continue for 4 or more days

Half-life: 24 hours

Elimination: Primarily in urine and feces

Oral:

Adults: Initial: 10 mg twice daily, increase by 10 mg every other day until optimum dose is achieved; usual range: 20-40 mg 2-3 times/day

Alcohol: Avoid use

GI irritation may be reduced by giving in divided doses

Blood pressure, pulse, urine output, orthostasis

May cause sedation, confusion, or dizziness

Concurrent use with low potency antipsychotics, TCAs and MAOIs may produce additive hypotension

No information available to require special precautions

No effects or complications reported

Avoid alcoholic beverages; if dizziness occurs, avoid sudden changes in posture; may cause nasal congestion and constricted pupils; may inhibit ejaculation; avoid cough, cold or allergy medications containing sympathomimetics

Monitor for orthostasis; assist with ambulation

Capsule, as hydrochloride: 10 mg