Yes

Analgesic, Urinary

Symptomatic relief of urinary burning, itching, frequency and urgency in association with urinary tract infection or following urologic procedures

B

Hypersensitivity to phenazopyridine or any component; kidney or liver disease

Does not treat infection, acts only as an analgesic; drug should be discontinued if skin or sclera develop a yellow color; use with caution in patients with renal impairment. Use of this agent in the elderly is limited since accumulation of phenazopyridine can occur in patients with renal insufficiency. It should not be used in patients with a Cl_cr <50 mL/minute.

1% to 10%:

Central nervous system: Headache, dizziness

Gastrointestinal: Stomach cramps

<1%: Vertigo, skin pigmentation, rash, methemoglobinemia, hemolytic anemia, hepatitis, acute renal failure

Symptoms of overdose include methemoglobinemia, hemolytic anemia, skin pigmentation, renal and hepatic impairment

Antidote is methylene blue 1-2 mg/kg I.V. for methemoglobinemia

No data reported

An azo dye which exerts local anesthetic or analgesic action on urinary tract mucosa through an unknown mechanism

Metabolism: In the liver and other tissues

Elimination: In urine (where it exerts its action); renal excretion (as unchanged drug) is rapid and accounts for 65% of the drug's elimination

Oral:

Adults: 100-200 mg 3 times/day after meals for 2 days when used concomitantly with an antibacterial agent

Dosing interval in renal impairment:

Cl_cr 50-80 mL/minute: Administer every 8-16 hours

Cl_cr <50 mL/minute: Avoid use

Should be administered after meals

Phenazopyridine may cause delayed reactions with glucose oxidase reagents (Clinistix®, Tes-Tape®); occasional false-positive tests occur with Tes-Tape®; cupric sulfate tests (Clinitest®) are not affected; interference may also occur with urine ketone tests (Acetest®, Ketostix®) and urinary protein tests; tests for urinary steroids and porphyrins may also occur

May cause dizziness

None reported

No information available to require special precautions

No effects or complications reported

Take prescribed dose after meals. May discolor urine (orange/yellow) or feces (orange/red); this is normal but will stain fabric. Report persistent headache, dizziness, or stomach cramping. Breast-feeding precautions: Consult prescriber if breast-feeding.

Colors urine orange or red; stains clothing and is difficult to remove

Tablet, as hydrochloride:

Baridium®, Geridium®, Pyridiate®, Pyridium®, Urodine®, Urogesic®: 100 mg

Geridium®, Phenazodine®, Pyridium®, Urodine®: 200 mg

A 10 mg/mL suspension may be made by crushing three 200 mg tablets. Mix with a small amount of distilled water or glycerin. Add 20 mL Cologel® and levigate until a uniform mixture is obtained. Add sufficient 2:1 simple syrup/cherry syrup mixture to make a final volume of 60 mL. Store in an amber container. Label "shake well". Stability is 60 days refrigerated.