No

Antibiotic, Penicillin

May be used in specific situations in the treatment of streptococcal infections

B

Known hypersensitivity to penicillin or any component

Use with caution in patients with impaired renal function, impaired cardiac function or seizure disorder

1% to 10%:

Hematologic: Positive Coombs' reaction, hemolytic anemia

Renal: Interstitial nephritis

Miscellaneous: Hypersensitivity reactions, Jarisch-Herxheimer reaction

Many beta-lactam-containing antibiotics have the potential to cause neuromuscular hyperirritability or convulsive seizures

Hemodialysis may be helpful to aid in the removal of the drug from the blood, otherwise most treatment is supportive or symptom directed

Probenecid, tetracyclines, methotrexate, aminoglycosides

Store in the refrigerator

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

I.M.:

<30 lb: 600,000 units in a single dose

30-60 lb: 900,000 units to 1.2 million units in a single dose

Children >60 lb and Adults: 2.4 million units in a single dose

Administer by deep I.M. injection in the upper outer quadrant of the buttock; give around-the-clock rather than 4 times/day, 3 times/day, etc, (ie, 12-6-12-6, not 9-1-5-9) to promote less variation in peak and trough serum levels; do not administer I.V., intravascularly, or intra-arterially. In infants and children, I.M. injections should be made into the midlateral muscle of the thigh.

Observe for signs and symptoms for anaphylaxis during first dose

May interfere with urinary glucose tests using cupric sulfate (Benedict's solution, Clinitest®); may inactivate aminoglycosides in vitro; positive Coombs' [direct], increased protein

No information available to require special precautions

No effects or complications reported

Administer by deep I.M. injection in the upper outer quadrant of the buttock

Injection:

300,000 units [150,000 units each of penicillin g benzathine and penicillin g procaine] (10 mL)

600,000 units [300,000 units each penicillin g benzathine and penicillin g procaine] (1 mL)

1,200,000 units [600,000 units each penicillin g benzathine and penicillin g procaine] (2 mL)

2,400,000 units [1,200,000 units each penicillin g benzathine and penicillin g procaine] (4 mL)

Injection: Penicillin g benzathine 900,000 units and penicillin g procaine 300,000 units per dose (2 mL)