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Pronunciation |
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(PAN
kree a
tin) |
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U.S. Brand
Names |
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Creon®; Digepepsin®;
Donnazyme®; Hi-Vegi-Lip® |
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Generic
Available |
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No |
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Pharmacological Index |
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Enzyme |
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Use |
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Replacement therapy in symptomatic treatment of malabsorption syndrome caused
by pancreatic insufficiency |
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Pregnancy Risk
Factor |
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C |
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Adverse
Reactions |
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1% to 10%: High doses:
Endocrine & metabolic: Hyperuricemia
Gastrointestinal: Nausea, cramps, constipation, diarrhea
Ocular: Lacrimation
Renal: Hyperuricosuria
Respiratory: Sneezing
<1%:
Dermatologic: Rash
Gastrointestinal: Irritation of the mouth
Respiratory: Dyspnea, bronchospasm |
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Usual Dosage |
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The following dosage recommendations are only an approximation for initial
dosages. The actual dosage will depend on the digestive requirements of the
individual patient.
<1 year: 2000 units of lipase with meals/feedings
1-6 years: 4000-8000 units of lipase with meals and 4,000 units with snacks
7-12 years: 4000-12,000 units of lipase with meals and snacks
Adults: 4000-16,000 units of lipase with meals and with snacks
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Dietary
Considerations |
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May be administered with food |
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Administration |
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Oral: Swallow capsules/tablets whole; retention in the mouth before
swallowing may cause mucosal irritation and stomatitis; for infants give with a
small amount of formula |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Retention in the mouth before swallowing may cause mucosal irritation and
stomatitis; do not crush or chew; patient should swallow whole; avoid inhaling
powder dosage form |
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Nursing
Implications |
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Monitor stool fat content |
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Dosage Forms |
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Capsule, enteric coated microspheres (Creon®): Lipase
8000 units, amylase 30,000 units, protease 13,000 units and pancreatin 300 mg
Tablet:
Digepepsin®: Pancreatin 300 mg, pepsin 250 mg, and bile
salts 150 mg
Donnazyme®: Lipase 1000 units, amylase 12,500 units,
protease 12,500 units and pancreatin 500 mg
Hi-Vegi-Lip®: Lipase 4800 units, amylase 60,000 units,
protease 60,000 units and pancreatin 2400 mg
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