No

Antifungal Agent, Topical

Treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm)

B

Hypersensitivity to this agent; not for ophthalmic use

May cause irritation during therapy; if a sensitivity to oxiconazole occurs, therapy should be discontinued; avoid contact with eyes or vagina

1% to 10%:

Local: Transient burning, local irritation, stinging, dryness

CYP3A3/4 enzyme inhibitor

The cytoplasmic membrane integrity of fungi is destroyed by oxiconazole which exerts a fungicidal activity through inhibition of ergosterol synthesis. Effective for treatment of tinea pedis, tinea cruris, and tinea corporis. Active against Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton violaceum, Microsporum canis, Microsporum audouini, Microsporum gypseum, Epidermophyton floccosum, Candida albicans, and Malassezia furfur.

Absorption: In each layer of the dermis; very little is absorbed systemically after one topical dose

Distribution: To each layer of the dermis; excreted in breast milk

Elimination: <0.3% excreted in urine

Children and Adults: Topical: Apply once to twice daily to affected areas for 2 weeks (tinea corporis/tinea cruris) to 1 month (tinea pedis)

None noted

None noted

No information available to require special precautions

No effects or complications reported

External use only; discontinue if sensitivity or chemical irritation occurs, contact physician if condition fails to improve in 3-4 days

External use only; discontinue if sensitivity or chemical irritation occurs, contact physician if condition fails to improve in 3-4 days

Cream, as nitrate: 1% (15 g, 30 g, 60 g)

Lotion, as nitrate: 1% (30 mL)