|
Pronunciation |
|
(oks
AM ni
kwin) |
|
|
U.S. Brand
Names |
|
Vansil™ |
|
|
Generic
Available |
|
No |
|
|
Pharmacological Index |
|
Anthelmintic |
|
|
Use |
|
Treatment of all stages of Schistosoma mansoni
infection |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Warnings/Precautions |
|
Rare epileptiform convulsions have been observed within the first few hours
of administration, especially in patients with a history of CNS
pathology |
|
|
Adverse
Reactions |
|
>10%: Central nervous system: Dizziness, drowsiness, headache
<10%:
Central nervous system: Insomnia, malaise, hallucinations, behavior changes
Gastrointestinal: GI effects, orange/red discoloration of urine
Hepatic: Elevated LFTs
Dermatologic: Rash, urticaria, pruritus
Renal: Proteinuria |
|
|
Drug
Interactions |
|
May be synergistic with praziquantel |
|
|
Mechanism of
Action |
|
Not fully elucidated; causes worms to dislodge from their usual site of
residence (mesenteric veins to the liver) by paralysis and contraction of
musculature and subsequently phagocytized |
|
|
Pharmacodynamics/Kinetics |
|
Absorption: Oral: Well absorbed
Metabolism: Extensive in the GI tract via oxidation
Half-life: 1-2.5 hours
Time to peak: 1-3 hours
Elimination: <2% unchanged in urine; up to 75% of metabolites excreted in
urine |
|
|
Usual Dosage |
|
Oral:
Adults: 12-15 mg/kg as a single dose |
|
|
Dietary
Considerations |
|
May be administered with food |
|
|
Test
Interactions |
|
May interfere with spectrometric or color reaction
urinalysis |
|
|
Mental Health: Effects
on Mental Status |
|
Dizziness and drowsiness are common; may cause insomnia or
hallucinations |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Take with food |
|
|
Dosage Forms |
|
Capsule: 250 mg |
|
|
References |
|
"Drugs for Parasitic Infections," Med Lett Drugs Ther, 1993,
35(911):111-22. |
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