| Pronunciation |
 (nye
STAT in & trye am SIN oh
lone) |
 |
| U.S. Brand Names |
| Mycogen II Topical; Mycolog®-II Topical; Myconel® Topical; Myco-Triacet® II; Mytrex® F Topical; N.G.T.® Topical; Tri-Statin® II Topical |
|
| Generic Available |
|
Yes |
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| Synonyms |
| Triamcinolone and Nystatin |
|
| Pharmacological Index |
|
Antifungal Agent, Topical; Corticosteroid, Topical |
|
| Use |
|
Treatment of cutaneous candidiasis |
|
| Pregnancy Risk Factor |
|
C |
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| Contraindications |
|
Known hypersensitivity to nystatin or triamcinolone |
|
| Warnings/Precautions |
|
Avoid use of occlusive dressings; limit therapy to least amount necessary for effective therapy, pediatric patients may be more susceptible to HPA axis suppression due to larger BSA to weight ratio |
|
| Adverse Reactions |
|
1% to 10%: Local: Burning, itching, irritation Miscellaneous: Increased incidence of secondary infection |
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| Drug Interactions |
|
No data reported |
|
| Mechanism of Action |
|
Nystatin is an antifungal agent that binds to sterols in fungal cell membrane, changing the cell wall permeability allowing for leakage of cellular contents. Triamcinolone is a synthetic corticosteroid; it decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system reducing activity and volume of the lymphatic system. It suppresses adrenal function at high doses. |
|
| Usual Dosage |
|
Children and Adults: Topical: Apply sparingly 2-4 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary. |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Patient Information |
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See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to get pregnant. Consult prescriber if breast-feeding. |
|
| Nursing Implications |
|
External use only; do not use on open wounds; apply sparingly to occlusive dressings; should not be used in the presence of open or weeping lesions |
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| Dosage Forms |
|
Cream: Nystatin 100,000 units and triamcinolone acetonide 0.1% (1.5 g, 15 g, 30 g, 60 g, 120 g) Ointment, topical: Nystatin 100,000 units and triamcinolone acetonide 0.1% (15 g, 30 g, 60 g, 120 g) |
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