Yes

Antibiotic, Topical

Short-term as a continuous irrigant or rinse in the urinary bladder to prevent bacteriuria and gram-negative rod septicemia associated with the use of indwelling catheters; to help prevent infection in minor cuts, scrapes, and burns

C/D (for G.U. irrigant)

Hypersensitivity to neomycin or polymyxin B or any component; ophthalmic use for topical cream

1% to 10%:

Genitourinary: Bladder irritation

Local: Burning

Neuromuscular & skeletal: Neuromuscular blockade

Otic: Ototoxicity

Renal: Nephrotoxicity

No data reported

Store irrigation solution in refrigerator; aseptic prepared dilutions (1 mL/1 L) should be stored in the refrigerator and discarded after 48 hours

Refer to individual monographs

Absorption: Topical: Not absorbed following application to intact skin; absorbed through denuded or abraded skin, peritoneum, wounds, or ulcers

Children and Adults:

Topical: Apply cream 1-4 times/day to affected area

Bladder irrigant: Do not inject irrigant solution; concentrated irrigant solution must be diluted in 1 L normal saline before administration; connect irrigation container to the inflow lumen of a 3-way catheter to permit continuous irrigation of the urinary bladder

None reported

None reported

No information available to require special precautions

No effects or complications reported

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

Monitor urinalysis

Cream: Neomycin sulfate 3.5 mg and polymyxin B sulfate 10,000 units per g (0.94 g, 15 g)

Solution, irrigant: Neomycin sulfate 40 mg and polymyxin B sulfate 200,000 units per mL (1 mL, 20 mL)