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Look Up > Drugs > Neomycin, Polymyxin B, and Prednisolone
Neomycin, Polymyxin B, and Prednisolone
Pronunciation
U.S. Brand Names
Generic Available
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Adverse Reactions
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(nee oh MYE sin, pol i MIKS in bee, & pred NIS oh lone)

U.S. Brand Names
Poly-Pred® Ophthalmic Suspension

Generic Available

Yes


Synonyms
polymyxin b, neomycin, and prednisolone; prednisolone, neomycin, and polymyxin b

Pharmacological Index

Antibiotic/Corticosteroid, Ophthalmic


Use

Steroid-responsive inflammatory ocular condition in which bacterial infection or a risk of bacterial ocular infection exists


Pregnancy Risk Factor

C


Adverse Reactions

1% to 10%:

Ocular: Increased intraocular pressure, glaucoma, optic nerve damage, cataracts, conjunctival sensitization


Drug Interactions

No data reported


Mechanism of Action

Refer to individual monographs


Pharmacodynamics/Kinetics

Refer to individual monographs


Usual Dosage

Children and Adults: Ophthalmic: Instill 1-2 drops every 3-4 hours; acute infections may require every 30-minute instillation initially with frequency of administration reduced as the infection is brought under control. To treat the lids: Instill 1-2 drops every 3-4 hours, close the eye and rub the excess on the lids and lid margins.


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

Ophthalmic: May cause sensitivity to bright light; may cause temporary blurring of vision or stinging following administration, but discontinue product and see physician if problems persist or increase; to use, tilt head back and place medication in conjunctival sac and close eyes; apply light pressure on lacrimal sac for 1 minute


Nursing Implications

Shake suspension before using


Dosage Forms

Suspension, ophthalmic: Neomycin sulfate 0.35%, polymyxin B sulfate 10,000 units, and prednisolone acetate 0.5% per mL (5 mL, 10 mL)


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