|
Pronunciation |
|
(nee
oh MYE sin, pol i MIKS in bee,
& hye droe KOR ti sone) |
|
|
U.S. Brand
Names |
|
AK-Spore® H.C. Ophthalmic
Suspension; AK-Spore® H.C. Otic; AntibiOtic® Otic;
Cortatrigen® Otic; Cortisporin® Ophthalmic Suspension;
Cortisporin® Otic; Cortisporin® Topical Cream;
Octicair® Otic; Otic-Care® Otic; Otocort® Otic;
Otosporin® Otic; Pediotic® Otic; UAD
Otic® |
|
|
Generic
Available |
|
Yes |
|
|
Synonyms |
|
hydrocortisone, neomycin, and polymyxin b; polymyxin b, neomycin, and
hydrocortisone |
|
|
Pharmacological Index |
|
Antibiotic/Corticosteroid, Ophthalmic; Antibiotic/Corticosteroid, Otic; Topical
Skin Product |
|
|
Use |
|
Steroid-responsive inflammatory condition for which a corticosteroid is
indicated and where bacterial infection or a risk of bacterial infection
exists |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Adverse
Reactions |
|
>10%: Miscellaneous: Hypersensitivity
1% to 10%:
Dermatologic: Contact dermatitis, erythema, rash, urticaria
Genitourinary: Bladder irritation
Local: Burning, itching, swelling, pain, stinging
Neuromuscular & skeletal: Neuromuscular blockade
Ocular: Increased intraocular pressure, glaucoma, cataracts, conjunctival
erythema
Otic: Ototoxicity
Renal: Nephrotoxicity
Miscellaneous: Sensitization to neomycin, secondary infections
|
|
|
Drug
Interactions |
|
No data reported |
|
|
Mechanism of
Action |
|
Refer to individual monographs for neomycin, Polymyxin B, and
Hydrocortisone |
|
|
Usual Dosage |
|
Duration of use should be limited to 10 days unless otherwise directed by the
physician
Otic:
Children: Instill 3 drops into affected ear 3-4 times/day
Adults: Instill 4 drops 3-4 times/day; otic suspension is the preferred otic
preparation
Children and Adults:
Ophthalmic: Drops: Instill 1-2 drops 2-4 times/day, or more frequently as
required for severe infections; in acute infections, instill 1-2 drops every
15-30 minutes gradually reducing the frequency of administration as the
infection is controlled
Topical: Apply a thin layer 1-4 times/day. Therapy should be discontinued
when control is achieved; if no improvement is seen, reassessment of diagnosis
may be necessary. |
|
|
Administration |
|
Shake suspension well before using. Otic solution should not be used when the
integrity of the tympanic membrane is in question. |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Otic: Hold container in hand to warm; if drops are in suspension form, shake
well for approximately 10 seconds, lie on your side with affected ear up; for
adults hold the ear lobe up and back, for children hold the ear lobe down and
back; instill drops in ear without inserting dropper into ear; maintain tilted
ear for 2 minutes
Ophthalmic: May cause sensitivity to bright light; may cause temporary
blurring of vision or stinging following administration, but discontinue product
and see physician if problems persist or increase; to use, tilt head back and
place medication in conjunctival sac and close eyes; apply light pressure on
lacrimal sac for 1 minute
Cream: Discontinue product if irritation persists or increases
|
|
|
Nursing
Implications |
|
Otic suspension is the preferred otic preparation; otic suspension can be
used for the treatment of infections of mastoidectomy and fenestration cavities
caused by susceptible organisms; otic solution is used only for
superficial infections of the external auditory canal (ie, swimmer's
ear) |
|
|
Dosage Forms |
|
Cream, topical: Neomycin sulfate 5 mg, polymyxin B sulfate 10,000 units, and
hydrocortisone 10 mg per mL (7.5 g)
Solution, otic: Neomycin sulfate 5 mg, polymyxin B sulfate 10,000 units, and
hydrocortisone 10 mg per mL (10 mL)
Suspension:
Ophthalmic: Neomycin sulfate 5 mg, polymyxin B sulfate 10,000 units, and
hydrocortisone 10 mg per mL (7.5 mL)
Otic: Neomycin sulfate 5 mg, polymyxin B sulfate 10,000 units, and
hydrocortisone 10 mg per mL (10 mL) |
|
Copyright © 1978-2000 Lexi-Comp Inc. All Rights Reserved
|