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Pronunciation |
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(nee
oh MYE sin, pol i MIKS in bee,
& gram i SYE din) |
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U.S. Brand
Names |
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AK-Spore® Ophthalmic Solution;
Neosporin® Ophthalmic
Solution |
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Generic
Available |
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Yes |
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Synonyms |
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gramicidin, neomycin, and polymyxin b; polymyxin b, neomycin, and
gramicidin |
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Pharmacological Index |
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Antibiotic, Ophthalmic |
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Use |
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Treatment of superficial ocular infection, infection prophylaxis in minor
skin abrasions |
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Pregnancy Risk
Factor |
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C |
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Contraindications |
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Hypersensitivity to neomycin, polymyxin B, gramicidin or any
component |
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Warnings/Precautions |
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Symptoms of neomycin sensitization include itching, reddening, edema, failure
to heal; prolonged use may result in glaucoma, defects in visual acuity,
posterior subcapsular cataract formation, and secondary ocular
infections |
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Adverse
Reactions |
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1% to 10%:
Dermatologic: Itching
Local: Reddening, failure to heal
Ocular: Low grade conjunctivitis |
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Drug
Interactions |
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No data reported |
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Mechanism of
Action |
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Interferes with bacterial protein synthesis by binding to 30S ribosomal
subunits; binds to phospholipids, alters permeability, and damages the bacterial
cytoplasmic membrane permitting leakage of intracellular
constituents |
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Usual Dosage |
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Children and Adults: Ophthalmic: Instill 1-2 drops 4-6 times/day or more
frequently as required for severe infections |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Tilt head back, place medication in conjunctival sac, and close eyes; apply
finger pressure on lacrimal sac for 1 minute following
instillation |
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Nursing
Implications |
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Tilt head back, place medication in conjunctival sac, and close eyes; apply
finger pressure on lacrimal sac for 1 minute following
instillation |
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Dosage Forms |
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Solution, ophthalmic: Neomycin sulfate 1.75 mg, polymyxin B sulfate 10,000
units, and gramicidin 0.025 mg per mL (2 mL, 10
mL) |
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