|
Pronunciation |
|
(nee
oh MYE sin, pol i MIKS in bee,
& deks a METH a sone) |
|
|
U.S. Brand
Names |
|
AK-Trol®; Dexacidin®;
Dexasporin®; Maxitrol® |
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|
Generic
Available |
|
Yes |
|
|
Synonyms |
|
dexamethasone, neomycin, and polymyxin b; polymyxin b, neomycin, and
dexamethasone |
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|
Pharmacological Index |
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Antibiotic/Corticosteroid, Ophthalmic |
|
|
Use |
|
Steroid-responsive inflammatory ocular conditions in which a corticosteroid
is indicated and where bacterial infection or a risk of bacterial infection
exists |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Adverse
Reactions |
|
1% to 10%:
Ocular: Cutaneous sensitization, eye pain, development of glaucoma, cataract,
increased intraocular pressure, optic nerve damage |
|
|
Drug
Interactions |
|
No data reported |
|
|
Mechanism of
Action |
|
Refer to individual monographs |
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|
Pharmacodynamics/Kinetics |
|
Refer to individual monographs |
|
|
Usual Dosage |
|
Children and Adults: Ophthalmic:
Solution: Instill 1-2 drops into affected eye(s) every 3-4 hours; in severe
disease, drops may be used hourly and tapered to discontinuation
|
|
|
Administration |
|
Tilt head back, place medication in conjunctival sac and close
eyes |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Notify physician if condition worsens or does not improve in 3-4
days |
|
|
Nursing
Implications |
|
Shake well before using
Monitor intraocular pressure with use >10 days |
|
|
Dosage Forms |
|
Ophthalmic:
Suspension: Neomycin sulfate 3.5 mg, polymyxin B sulfate 10,000 units and
dexamethasone 0.1% per mL (5 mL, 10 mL) |
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