|
Pronunciation |
|
(NAF
ti
feen) |
|
|
U.S. Brand
Names |
|
Naftin® |
|
|
Generic
Available |
|
No |
|
|
Synonyms |
|
Naftifine Hydrochloride |
|
|
Pharmacological Index |
|
Antifungal Agent, Topical |
|
|
Use |
|
Topical treatment of tinea cruris (jock itch), tinea corporis (ringworm), and
tinea pedis (athlete's foot) |
|
|
Pregnancy Risk
Factor |
|
B |
|
|
Contraindications |
|
Hypersensitivity to any component |
|
|
Warnings/Precautions |
|
For external use only |
|
|
Adverse
Reactions |
|
>10%: Local: Burning, stinging
1% to 10%:
Dermatologic: Erythema, itching
Local: Dryness, irritation |
|
|
Drug
Interactions |
|
No data reported |
|
|
Mechanism of
Action |
|
Synthetic, broad-spectrum antifungal agent in the allylamine class; appears
to have both fungistatic and fungicidal activity. Exhibits antifungal activity
by selectively inhibiting the enzyme squalene epoxidase in a dose-dependent
manner which results in the primary sterol, ergosterol, within the fungal
membrane not being synthesized. |
|
|
Pharmacodynamics/Kinetics |
|
Absorption: Systemic, 6% for cream, less than or equal to 4% for gel
Half-life: 2-3 days
Elimination: Metabolites excreted in urine and feces |
|
|
Usual Dosage |
|
Adults: Topical: Apply cream once daily and gel twice daily (morning and
evening) for up to 4 weeks |
|
|
Mental Health: Effects
on Mental Status |
|
None noted |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None noted |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
External use only; avoid eyes, mouth, and other mucous membranes; do not use
occlusive dressings unless directed to do so; discontinue if irritation or
sensitivity develops; wash hands after application |
|
|
Nursing
Implications |
|
External use only; avoid eyes, mouth, and other mucous membranes; do not use
occlusive dressings unless directed to do so; discontinue if irritation or
sensitivity develops; wash hands after application |
|
|
Dosage Forms |
|
Cream, as hydrochloride: 1% (15 g, 30 g, 60 g)
Gel, topical, as hydrochloride: 1% (20 g, 40 g, 60 g)
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