| Pronunciation |
 (myoo
PEER oh
sin) |
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| U.S. Brand Names |
| Bactroban®; Bactroban® Nasal |
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| Generic Available |
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No |
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| Synonyms |
| Mupirocin Calcium; Pseudomonic Acid A |
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| Pharmacological Index |
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Antibiotic, Topical |
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| Use |
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Topical treatment of impetigo due to Staphylococcus aureus, beta-hemolytic Streptococcus, and S. pyogenes |
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| Pregnancy Risk Factor |
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B |
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| Contraindications |
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Known hypersensitivity to mupirocin or polyethylene glycol |
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| Warnings/Precautions |
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Potentially toxic amounts of polyethylene glycol contained in the vehicle may be absorbed percutaneously in patients with extensive burns or open wounds; prolonged use may result in over growth of nonsusceptible organisms; for external use only; not for treatment of pressure sores |
|
| Adverse Reactions |
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1% to 10%: Local: Burning, stinging, tenderness, edema, pain |
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| Drug Interactions |
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No data reported |
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| Stability |
|
Do not mix with Aquaphor®, coal tar solution, or salicylic acid |
|
| Mechanism of Action |
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Binds to bacterial isoleucyl transfer-RNA synthetase resulting in the inhibition of protein and RNA synthesis |
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| Pharmacodynamics/Kinetics |
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Absorption: Topical: Penetrates the outer layers of the skin; systemic absorption minimal through intact skin Protein binding: 95% Metabolism: Extensively to monic acid, principally in the liver and skin Half-life: 17-36 minutes Elimination: In urine |
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| Usual Dosage |
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Topical: Children and Adults: Apply small amount to affected area 2-5 times/day for 5-14 days Nasal: In adults (12 years of age and older), approximately one-half of the ointment from the single-use tube should be applied into one nostril and the other half into the other nostril twice daily for 5 days |
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| Mental Health: Effects on Mental Status |
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None noted |
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| Mental Health: Effects on Psychiatric Treatment |
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None noted |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Patient Information |
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For external use only. Wash hands before and after application. Apply this film over affected areas exactly as directed. Avoid getting in eyes. Report rash; persistent burning, stinging, swelling, itching, or pain. Breast-feeding precautions: Consult prescriber if breast-feeding. |
|
| Nursing Implications |
|
Not for treatment of pressure sores in elderly patients; contains polyethylene glycol vehicle |
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| Dosage Forms |
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Ointment, as calcium: Topical: 2% (15 g, 30 g) |
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| References |
|
Blumer JL, Lemon E, O'Horo J, et al, "Changing Therapy for Skin and Soft Tissue Infections in Children: Have We Come Full Circle?" Pediatr Infect Dis J, 1987, 6(1):117-22. Britton JW, Fajardo JE, and Krafte-Jacobs B, "Comparison of Mupirocin and Erythromycin in the Treatment of Impetigo," J Pediatr, 1990, 117(5):827-9. Goldfarb J, Crenshaw D, O'Horo J, et al, "Randomized Clinical Trial of Topical Mupirocin Versus Oral Erythromycin for Impetigo," Antimicrob Agents Chemother, 1988, 32(12):1780-3. |
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