Yes

Antibiotic, Tetracycline Derivative

Dental: Treatment of periodontitis associated with presence of Actinobacillus actinomycetemcomitans (AA); as adjunctive therapy in recurrent aphthous ulcers

Medical: Treatment of susceptible bacterial infections of both gram-negative and gram-positive organisms; acne, meningococcal carrier state

D

Hypersensitivity to minocycline, other tetracyclines, or any component; children <8 years of age

Should be avoided in renal insufficiency, children less than or equal to 8 years of age, pregnant and nursing women; photosensitivity reactions can occur with minocycline

>10%: Miscellaneous: Discoloration of teeth in children

1% to 10%:

Dermatologic: Photosensitivity

Gastrointestinal: Nausea, diarrhea

<1%: Pericarditis, increased intracranial pressure, bulging fontanels in infants, dermatologic effects, pruritus, exfoliative dermatitis, rash, pigmentation of nails, diabetes insipidus syndrome, vomiting, esophagitis, anorexia, abdominal cramps, paresthesia, acute renal failure, azotemia, superinfections, anaphylaxis

Symptoms of overdose include diabetes insipidus, nausea, anorexia, diarrhea

Following GI decontamination, supportive care only; fluid support may be required

Decreased effect with antacids (aluminum, calcium, zinc, or magnesium), bismuth salts, sodium bicarbonate, barbiturates, carbamazepine, hydantoins; decreased effect of oral contraceptives

Increased effect of warfarin

Inhibits bacterial protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; cell wall synthesis is not affected

Absorption: Well absorbed

Distribution: Crosses placenta; appears in breast milk; majority of a dose deposits for extended periods in fat

Protein binding: 70% to 75%

Half-life: 15 hours

Elimination: Eventually cleared renally

Children >8 years: Oral, I.V.: Initial: 4 mg/kg followed by 2 mg/kg/dose every 12 hours

Adults:

Infection: Oral, I.V.: 200 mg stat, 100 mg every 12 hours not to exceed 400 mg/24 hours

Acne: Oral: 50 mg 1-3 times/day

Hemodialysis: Not dialyzable (0% to 5%)

No data reported

Reports of memory disturbance, mood stabilizing and antidepressant effects

Barbiturates and carbamazepine may decrease the effects of tetracyclines; tetracyclines may decrease lithium clearance resulting in an increase in serum lithium levels and potential lithium toxicity; monitor serum lithium levels

No information available to require special precautions

Opportunistic "superinfection" with Candida albicans; tetracyclines are not recommended for use during pregnancy or in children less than or equal to 8 years of age since they have been reported to cause enamel hypoplasia and permanent teeth discoloration. The use of tetracycline's should only be used in these patients if other agents are contraindicated or alternative antimicrobials will not eradicate the organism. Long-term use associated with oral candidiasis.

Take as directed, at regular intervals around-the-clock. May be taken with food or milk. Complete full course of therapy; do not discontinue even if condition is resolved. You may experience sensitivity to sun; avoid sun, use sunblock, or wear protective clothing. Frequent small meals may help reduce nausea, vomiting or diarrhea. If diabetic, drug may cause false tests with Clinitest® urine glucose monitoring; use of glucose oxidase methods (Clinistix®) or serum glucose monitoring is preferable. Report rash or itching, respiratory difficulty, yellowing of skin or eyes, change in color of urine or stool, fever or chills, unusual bruising or bleeding, or unresolved diarrhea. Pregnancy/breast-feeding precautions: Do not get pregnant while taking this medication - Oral contraceptives effectiveness may be reduced; use appropriate barrier contraceptive measures. Breast-feeding is not recommended.

Infuse I.V. minocycline over 1 hour

Capsule:

As hydrochloride: 50 mg, 100 mg

As hydrochloride (Dynacin®, Vectrin®): 50 mg, 100 mg

Pellet-filled, as hydrochloride (Minocin®): 50 mg, 100 mg

Injection, as hydrochloride (Minocin® IV): 100 mg

Suspension, oral, as hydrochloride (Minocin®)50 mg/5 mL (60 mL)

Smilack JD, Wilson WR, and Cockerill FR 3d, "Tetracyclines, Chloramphenicol, Erythromycin, Clindamycin, and Metronidazole," Mayo Clin Proc, 1991, 66(12):1270-80.