|
| Pronunciation |
 (meth
il DOE pa & hye droe klor oh
THYE a zide) |
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| U.S. Brand Names |
| Aldoril® |
|
| Generic Available |
|
Yes |
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| Canadian Brand Names |
| Aldoril®-15; Aldoril®-25; Apo®-Methazide; Novo-Doparil; PMS-Dopazide |
|
| Synonyms |
| Hydrochlorothiazide and Methyldopa |
|
| Pharmacological Index |
|
Antihypertensive Agent, Combination |
|
| Use |
|
Management of moderate to severe hypertension |
|
| Pregnancy Risk Factor |
|
C |
|
| Usual Dosage |
|
Oral: 1 tablet 2-3 times/day for first 48 hours, then decrease or increase at intervals of not less than 2 days until an adequate response is achieved |
|
| Cardiovascular Considerations |
|
Combination therapy for the treatment of hypertension should be individualized for each patient. Potential advantages for methyldopa and hydrochlorothiazide combination therapy may include improved compliance and synergistic reductions in blood pressure with an accompanied reduction in side effects. Thiazide therapy improves cardiovascular outcomes in patients with hypertension. Methyldopa is infrequently used alone for the treatment of essential hypertension. |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
Anticholinergic side effects can cause a reduction of saliva production or secretion. This may result in discomfort and dental disease (ie, caries, oral candidiasis and periodontal disease) |
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| Patient Information |
|
See individual agents. Pregnancy precautions: Inform prescriber if you are or intend to get pregnant. |
|
| Dosage Forms |
|
Tablet: 25: Methyldopa 250 mg and hydrochlorothiazide 25 mg D30: Methyldopa 500 mg and hydrochlorothiazide 30 mg D50: Methyldopa 500 mg and hydrochlorothiazide 50 mg |
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