Yes

Skeletal Muscle Relaxant

Dental: Treatment of muscle spasm associated with acute temporomandibular joint pain

Medical: Adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal disorders

C/D (if full-dose aspirin in 3rd trimester)

Methocarbamol: Renal impairment, hypersensitivity to methocarbamol or any component

Aspirin: Bleeding disorders (factor VII or IX deficiencies), hypersensitivity to salicylates or other NSAIDs, tartrazine dye and asthma

Use aspirin with caution in patients with platelet and bleeding disorders, renal dysfunction, erosive gastritis, or peptic ulcer disease, previous nonreaction does not guarantee future safe taking of medication; do not use aspirin in children <16 years of age for chickenpox or flu symptoms due to the association with Reye's syndrome

Elderly are a high-risk population for adverse effects from nonsteroidal anti-inflammatory agents. As much as 60% of elderly with GI complications to NSAIDs can develop peptic ulceration and/or hemorrhage asymptomatically. Also, concomitant disease and drug use contribute to the risk for GI adverse effects. Use lowest effective dose for shortest period possible. Consider renal function decline with age. Use with caution in patients with history of asthma

Methocarbamol: >10%: Central nervous system: Drowsiness, dizziness, lightheadedness

Aspirin:

>10%: Gastrointestinal: Nausea, vomiting, dyspepsia, epigastric discomfort, heartburn, stomach pains

1% to 10%: Gastrointestinal: Ulceration

Methocarbamol: Increased effect/toxicity with CNS depressants

Aspirin: Concomitant use of aspirin may result in possible decreased serum concentration of NSAIDs; aspirin may antagonize effects of probenecid; aspirin may increase methotrexate serum levels. Aspirin may displace valproic acid from binding sites which can result in toxicity; warfarin and aspirin result in increased bleeding; NSAIDs and aspirin result in increased GI adverse effects.

Causes skeletal muscle relaxation by reducing the transmission of impulses from the spinal cord to skeletal muscle

Methocarbamol:

Absorption: Rapid

Onset of muscle relaxation: Oral: Within 30 minutes

Time to peak serum concentration: Oral: ~2 hours

Serum half-life: 1-2 hours

Aspirin:

Absorption: Rapid

Time to peak serum concentration: ~1-2 hours

Serum half-life:

Parent drug: 15-20 minutes

Salicylates (dose-dependent): From 3 hours at lower doses (300-600 mg), to 5-6 hours (after 1 g) to 10 hours with higher doses

Children >12 years and Adults: Oral: 2 tablets 4 times/day

Food decreases rate but not extent of absorption (oral)

No information available to require special precautions

Use with caution in patients with platelet and bleeding disorders, renal dysfunction, erosive gastritis, or peptic ulcer disease, previous nonreaction does not guarantee future safe taking of medication; use with caution in impaired hepatic function; do not use aspirin in children <16 years of age for chickenpox or flu symptoms due to the association with Reye's syndrome

Elderly are a high-risk population for adverse effects from nonsteroidal anti-inflammatory agents. As much as 60% of elderly with GI complications to NSAIDs can develop peptic ulceration and/or hemorrhage asymptomatically. Also, concomitant disease and drug use contribute to the risk for GI adverse effects. Use lowest effective dose for shortest period possible. Consider renal function decline with age. Use with caution in patients with history of asthma

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

Tablet: Methocarbamol 400 mg and aspirin 325 mg