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Mepenzolate
Pronunciation
U.S. Brand Names
Generic Available
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Adverse Reactions
Usual Dosage
Dietary Considerations
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Dosage Forms

Pronunciation
(me PEN zoe late)

U.S. Brand Names
Cantil®

Generic Available

No


Synonyms
Mepenzolate Bromide

Pharmacological Index

Anticholinergic Agent; Antispasmodic Agent, Gastrointestinal


Use

Management of peptic ulcer disease; inhibit salivation and excessive secretions in respiratory tract preoperatively


Pregnancy Risk Factor

C


Contraindications

Angle-closure glaucoma; acute hemorrhage; tachycardia; hypersensitivity to mepenzolate or any component; obstructive uropathy (ie, bladder neck obstruction due to prostatic hypertrophy); obstructive gastrointestinal disease (ie, pyloroduodenal stenosis, achalasia); paralytic ileus; intestinal atony of the debilitated or elderly patient; unstable cardiovascular status in acute hemorrhage; severe ulcerative colitis or toxic megacolon complicating ulcerative colitis; myasthenia gravis; allergic or idiosyncratic reactions of related compounds


Adverse Reactions

>10%:

Gastrointestinal: Constipation, xerostomia, dry throat

Dermatologic: Dry skin

Respiratory: Dry nose

Miscellaneous: Decreased diaphoresis

1% to 10%: Gastrointestinal: Dysphagia


Usual Dosage

Adults: Oral: 25-50 mg 4 times/day with meal and at bedtime


Dietary Considerations

May be administered with meals


Mental Health: Effects on Mental Status

May rarely cause confusion, amnesia, drowsiness, nervousness, or insomnia


Mental Health: Effects on Psychiatric Treatment

Concurrent use with psychotropics may produce additive drowsiness or anticholinergic side effects (dry mouth)


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

>10% of patients experience dry mouth


Dosage Forms

Tablet, as bromide: 25 mg


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