|
Pronunciation |
|
(ME
dri
sone) |
|
|
U.S. Brand
Names |
|
HMS
Liquifilm® |
|
|
Generic
Available |
|
No |
|
|
Pharmacological Index |
|
Corticosteroid, Ophthalmic |
|
|
Use |
|
Treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis,
ophthalmic epinephrine sensitivity reaction |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
Fungal, viral, or untreated pus-forming bacterial ocular infections; not for
use in iritis and uveitis |
|
|
Warnings/Precautions |
|
Prolonged use has been associated with the development of corneal or scleral
perforation and posterior subcapsular cataracts; may mask or enhance the
establishment of acute purulent untreated infections of the eye; effectiveness
and safety have not been established in children. Medrysone is a synthetic
corticosteroid; structurally related to progesterone; if no improvement after
several days of treatment, discontinue medrysone and institute other therapy;
duration of therapy: 3-4 days to several weeks dependent on type and severity of
disease; taper dose to avoid disease exacerbation. |
|
|
Adverse
Reactions |
|
1% to 10%: Ocular: Temporary mild blurred vision
<1%: Stinging, burning eyes, corneal thinning, increased intraocular
pressure, glaucoma, damage to the optic nerve, defects in visual activity,
cataracts, secondary ocular infection |
|
|
Overdosage/Toxicology |
|
Systemic toxicity is unlikely from the ophthalmic
preparation |
|
|
Mechanism of
Action |
|
Decreases inflammation by suppression of migration of polymorphonuclear
leukocytes and reversal of increased capillary permeability |
|
|
Pharmacodynamics/Kinetics |
|
Absorption: Through aqueous humor
Metabolism: Any drug absorbed is metabolized in the liver
Elimination: By the kidneys and feces |
|
|
Usual Dosage |
|
Children and Adults: Ophthalmic: Instill 1 drop in conjunctival sac 2-4
times/day up to every 4 hours; may use every 1-2 hours during first 1-2
days |
|
|
Monitoring
Parameters |
|
Intraocular pressure and periodic examination of lens (with prolonged
use) |
|
|
Mental Health: Effects
on Mental Status |
|
None reported |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
For ophthalmic use only. Shake before using. Apply prescribed amount as often
as directed. Wash hands before using and do not let tip of applicator touch eye
or contaminate tip of applicator. Tilt head back and look upward. Gently pull
down lower lid and put drop(s) in inner corner of eye. Close eye and roll
eyeball in all directions. Do not blink for
1/2
minute. Apply gentle pressure to inner corner of eye for 30 seconds. Wipe away
excess from skin around eye. Do not use any other eye preparation for at least
10 minutes. Do not touch tip of applicator to eye or contaminate tip of
applicator. Do not share medication with anyone else. May cause sensitivity to
bright light (dark glasses may help); temporary stinging or blurred vision may
occur. Inform prescriber if you experience eye pain, redness, burning, watering,
dryness, double vision, puffiness around eye, vision disturbances, or other
adverse eye response; worsening of condition or lack of improvement within 3-4
days. Pregnancy/breast-feeding precautions: Inform prescriber if you are
pregnant. Consult prescriber if breast-feeding. |
|
|
Nursing
Implications |
|
Shake well before using; do not touch dropper to the eye
Monitor intraocular pressure and periodic examination of lens (with prolonged
use) |
|
|
Dosage Forms |
|
Solution, ophthalmic: 1% (5 mL, 10
mL) |
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