Yes

Antacid; Laxative, Saline; Magnesium Salt

Short-term treatment of occasional constipation and symptoms of hyperacidity, magnesium replacement therapy

B

Patients with colostomy or an ileostomy, intestinal obstruction, fecal impaction, renal failure, appendicitis, hypersensitivity to any component

Use with caution in patients with severe renal impairment, (especially when doses are >50 mEq magnesium/day); hypermagnesemia and toxicity may occur due to decreased renal clearance of absorbed magnesium. Decreased renal function (Cl_cr <30 mL/minute) may result in toxicity; monitor for toxicity.

>10%: Gastrointestinal: Diarrhea

1% to 10%:

Cardiovascular: Hypotension

Endocrine & metabolic: Hypermagnesemia

Gastrointestinal: Abdominal cramps

Neuromuscular & skeletal: Muscle weakness

Respiratory: Respiratory depression

Magnesium antacids are also laxative and may cause diarrhea and hypokalemia; in patients with renal failure, magnesium may accumulate to toxic levels.

I.V. calcium (5-10 mEq) will reverse respiratory depression or heart block; in extreme cases, peritoneal dialysis or hemodialysis may be required.

Decreased effect: Decreased absorption of tetracyclines, digoxin, indomethacin, or iron salts

Promotes bowel evacuation by causing osmotic retention of fluid which distends the colon with increased peristaltic activity; reacts with hydrochloric acid in stomach to form magnesium chloride

Onset of laxative action: 4-8 hours

Elimination: Absorbed magnesium ions (up to 30%) are usually excreted by kidneys, unabsorbed drug is excreted in feces

Oral:

Laxative:

<2 years: 0.5 mL/kg/dose

2-5 years: 5-15 mL/day or in divided doses

6-12 years: 15-30 mL/day or in divided doses

greater than or equal to 12 years: 30-60 mL/day or in divided doses

Antacid:

Children: 2.5-5 mL as needed up to 4 times/day

Adults: 5-15 mL up to 4 times/day as needed

Dosing in renal impairment: Patients in severe renal failure should not receive magnesium due to toxicity from accumulation. Patients with a Cl_cr <25 mL/minute receiving magnesium should be monitored by serum magnesium levels.

May be administered with fluids, taste can be improved by following each dose with citrus fruit juice

Serum magnesium:

Adults: 1.5-2.5 mg/dL (1.2-2.0 mEq/L)

magnesium; protein, calcium (S), potassium (S)

None reported

None reported

No information available to require special precautions

Magnesium products may prevent gastrointestinal absorption of tetracyclines by forming a large ionized chelated molecule with the tetracyclines in the stomach. Tetracyclines should be given at least 1 hour before magnesium.

Dilute dose in water or juice, shake well

MOM concentrate is 3 times as potent as regular strength product

Liquid: 390 mg/5 mL (10 mL, 15 mL, 20 mL, 30 mL, 100 mL, 120 mL, 180 mL, 360 mL, 720 mL)

Liquid, concentrate: 10 mL equivalent to 30 mL milk of magnesia USP

Suspension, oral: 2.5 g/30 mL (10 mL, 15 mL, 30 mL)

Tablet: 300 mg, 600 mg

Chernow B, Smith J, Rainey TG, et al, "Hypomagnesemia: Implications for the Critical Care Specialist," Crit Care Med, 1982, 10(3):193-6.

Gams JG, "Clinical Significance of Magnesium: A Review," Drug Intell Clin Pharm, 1987, 21(3):240-6.