Yes

Magnesium Salt

Dietary supplement for treatment of magnesium deficiencies

Patients with heart block; severe renal disease

1% to 10%: Gastrointestinal: Diarrhea (excessive dose)

Increased effect of nondepolarizing neuromuscular blockers

Decreased absorption of aminoquinolones, digoxin, nitrofurantoin, penicillamine, and tetracyclines may occur with magnesium salts

Magnesium is important as a cofactor in many enzymatic reactions in the body involving protein synthesis and carbohydrate metabolism, (at least 300 enzymatic reactions require magnesium). Actions on lipoprotein lipase have been found to be important in reducing serum cholesterol and on sodium/potassium ATPase in promoting polarization (ie, neuromuscular functioning).

Absorption: Oral: 15% to 30%

The recommended dietary allowance (RDA) of magnesium is 4.5 mg/kg which is a total daily allowance of 350-400 mg for adult men and 280-300 mg for adult women. During pregnancy the RDA is 300 mg and during lactation the RDA is 355 mg.

Children: 3-6 mg/kg/day in divided doses 3-4 times/day; maximum: 400 mg/day

Adults: 54-483 mg/day in divided doses; refer to product labeling

Dosing in renal impairment: Patients in severe renal failure should not receive magnesium due to toxicity from accumulation. Patients with a Cl_cr <25 mL/minute receiving magnesium should be monitored by serum magnesium levels.

None reported

None reported

No information available to require special precautions

Magnesium products may prevent gastrointestinal absorption of tetracyclines by forming a large ionized chelated molecule with the tetracyclines in the stomach. Tetracyclines should be given at least 1 hour before magnesium.

Tablet: 500 mg [elemental magnesium 27 mg]