No

Antibiotic, Topical

Adjunct in the treatment of second and third degree burns to prevent septicemia caused by susceptible organisms such as Pseudomonas aeruginosa; prevention of graft loss of meshed autografts on excised burn wounds

C

Hypersensitivity to mafenide, sulfites, or any component

Use with caution in patients with renal impairment and in patients with G-6-PD deficiency; prolonged use may result in superinfection

>10%:

Central nervous system: Pain

Local: Burning sensation, excoriation

1% to 10%:

Cardiovascular: Facial edema

Dermatologic: Rash

Miscellaneous: Dyspnea

<1%: Erythema, hyperchloremia, metabolic acidosis, bone marrow suppression, hemolytic anemia, bleeding, porphyria, hyperventilation, tachypnea, hypersensitivity

No data reported

Mafenide 5% topical solution preparation:

Dissolve the 50 g mafenide acetate (Sulfamylon®) packet in 200 mL of either sterile water for irrigation or sterile saline for irrigation; (minimum solubility of 50 g of mafenide is in 200 mL of either solution)

Sterilize this solution by pushing through a 0.22 micron filter

Further dissolve this 200 mL of sterile Sulfamylon® solution in 800 mL of the initial diluent (either sterile water for irrigation or sterile water for irrigation)

This solution is stable and sterile for a total of 48 hours at room temperature

Note: Mafenide acetate topical solution CANNOT be mixed with nystatin due to reduced activity of mafenide

Note: Pilot in vitro studies: Silvadene® and Furacin® cream combined with nystatin cream were equally effective against the microorganisms as were the individual drugs. However, Sulfamylon® cream combined with nystatin lost its antimicrobial capability. [J Burn Care Rehabil 1989;109(6):508-11.]

Interferes with bacterial folic acid synthesis through competitive inhibition of para-aminobenzoic acid

Absorption: Diffuses through devascularized areas and is rapidly absorbed from burned surface

Metabolism: To para-carboxybenzene sulfonamide which is a carbonic anhydrase inhibitor

Time to peak serum concentration: Topical: 2-4 hours

Elimination: In urine as metabolites

Children and Adults: Topical: Apply once or twice daily with a sterile gloved hand; apply to a thickness of approximately 16 mm; the burned area should be covered with cream at all times

Acid base balance

No information available to require special precautions

No effects or complications reported

For external use only. Apply exactly as directed with sterile gloved hand so that burned areas are covered with cream at all times. Avoid getting in eyes. Report facial swelling, skin rash, unusual bleeding, difficulty breathing, or signs of infections. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

For external use only

Monitor acid base balance

Cream, topical, as acetate: 85 mg/g (56.7 g, 113.4 g, 411 g)

Powder, topical: 5% (50 g)