| Pronunciation |
 (eye
SOKS syoo
preen) |
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| U.S. Brand Names |
| Vasodilan® |
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| Generic Available |
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Yes |
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| Synonyms |
| Isoxsuprine Hydrochloride |
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| Pharmacological Index |
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Vasodilator |
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| Use |
|
Treatment of peripheral vascular diseases, such as arteriosclerosis obliterans and Raynaud's disease |
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| Pregnancy Risk Factor |
|
C |
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| Contraindications |
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Presence of arterial bleeding; do not administer immediately postpartum |
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| Adverse Reactions |
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1% to 10%: Gastrointestinal: Nausea, vomiting |
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| Drug Interactions |
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May enhance effects of other vasodilators/hypotensive agents; use with caution in elderly |
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| Mechanism of Action |
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In studies on normal human subjects, isoxsuprine increases muscle blood flow, but skin blood flow is usually unaffected. Rather than increasing muscle blood flow by beta-receptor stimulation, isoxsuprine probably has a direct action on vascular smooth muscle. The generally accepted mechanism of action of isoxsuprine on the uterus is beta-adrenergic stimulation. Isoxsuprine was shown to inhibit prostaglandin synthetase at high serum concentrations, with low concentrations there was an increase in the P-G synthesis. |
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| Pharmacodynamics/Kinetics |
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Absorption: Nearly complete Serum half-life, serum: 1.25 hours mean Time to peak serum concentration: Oral, I.M.: Within 1 hour |
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| Usual Dosage |
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Adults: 10-20 mg 3-4 times/day; start with lower dose in elderly due to potential hypotension |
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| Mental Health: Effects on Mental Status |
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None reported |
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| Mental Health: Effects on Psychiatric Treatment |
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None reported |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Patient Information |
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May cause skin rash; discontinue use if rash occurs; arise slowly from prolonged sitting or lying position |
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| Nursing Implications |
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May cause skin rash; discontinue use if rash occurs; arise slowly from prolonged sitting or lying position |
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| Dosage Forms |
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Tablet, as hydrochloride: 10 mg, 20 mg |
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| References |
|
Erwin WG, "Senile Dementia of the Alzheimer Type," Clin Pharm, 1984, 3:497-504. Waters C, "Cognitive Enhancing Agents: Current Status in the Treatment of Alzheimer's Disease," Can J Neurol Sci, 1988, 15:249-56. Yesavage JA, Tinklenberg JR, Hollister LE, et al, "Vasodilators in Senile Dementias: A Review of the Literature," Arch Gen Psychiatry, 1979, 36:220-3. |
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