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Pronunciation |
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(eye
soe FLURE oh
fate) |
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U.S. Brand
Names |
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Floropryl®
Ophthalmic |
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Generic
Available |
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No |
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Synonyms |
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DFP; Diisopropyl Fluorophosphate; Dyflos; Fluostigmin |
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Pharmacological Index |
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Acetylcholinesterase Inhibitor; Ophthalmic Agent, Antiglaucoma; Ophthalmic
Agent, Miotic |
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Use |
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Treat primary open-angle glaucoma and conditions that obstruct aqueous
outflow and to treat accommodative convergent strabismus |
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Pregnancy Risk
Factor |
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X |
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Contraindications |
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Active uveal inflammation, angle-closure (narrow-angle) glaucoma, known
hypersensitivity to isoflurophate, pregnancy |
|
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Warnings/Precautions |
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May retard corneal healing; because of the tendency to produce more severe
adverse effects, use the lowest dose possible; keep frequency of use to a
minimum to avoid cyst formation; some products may contain
sulfites |
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Adverse
Reactions |
|
1% to 10%: Ocular: Stinging, burning eyes, myopia, visual blurring
<1%: Bradycardia, hypotension, flushing, nausea, vomiting, diarrhea,
muscle weakness, retinal detachment, browache, miosis, twitching eyelids,
watering eyes, dyspnea, diaphoresis |
|
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Overdosage/Toxicology |
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Symptoms of overdose include excessive salivation, urinary incontinence,
dyspnea, diarrhea, profuse sweating
If systemic effects occur, administer parenteral atropine; for severe muscle
weakness; pralidoxime may be used in addition to atropine |
|
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Drug
Interactions |
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Increased toxicity: Succinylcholine, systemic anticholinesterases, carbamate
or organic phosphate insecticides, may decrease cholinesterase
levels |
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Stability |
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Protect from moisture, freezing, excessive heat |
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Mechanism of
Action |
|
Cholinesterase inhibitor that causes contraction of the iris and ciliary
muscles producing miosis, reduced intraocular pressure, and increased aqueous
humor outflow |
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Pharmacodynamics/Kinetics |
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Peak IOP reduction: 24 hours; Duration: 1 week
Onset of miosis: Within 5-10 minutes; Duration: Up to 4 weeks
|
|
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Usual Dosage |
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Adults: Ophthalmic:
Strabismus: Instill 0.25" strip to each eye every night for 2 weeks then
reduce to 0.25" every other night to once weekly for 2 months
|
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Mental Health: Effects
on Mental Status |
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None reported |
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Mental Health:
Effects on Psychiatric
Treatment |
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None reported |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Notify physician if abdominal cramps, diarrhea, or salivation
occur |
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Nursing
Implications |
|
Keep tube tightly closed to prevent absorption of moisture and loss of
potency |
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Dosage Forms |
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Ointment, ophthalmic: 0.025% in polyethylene mineral oil gel (3.5
g) |
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