Yes

Adrenergic Agonist Agent; Bronchodilator; Sympathomimetic

Bronchodilator in bronchial asthma and for reversible bronchospasm occurring with bronchitis and emphysema

C

Known hypersensitivity to isoetharine

Excessive or prolonged use may result in decreased effectiveness

1% to 10%:

Cardiovascular: Tachycardia, hypertension, pounding heartbeat

Central nervous system: Dizziness, lightheadedness, headache, nervousness, insomnia

Gastrointestinal: Xerostomia, nausea, vomiting

Neuromuscular & skeletal: Trembling, weakness

<1%: Paradoxical bronchospasm

Symptoms of overdose include nausea, vomiting, hypertension, tremors; beta-adrenergic stimulation can cause increased heart rate, decreased blood pressure, and CNS excitation

Heart rate can be treated with beta-blockers, decreased blood pressure can be treated with pure alpha-adrenergic agents, diazepam 0.07 mg/kg can be used for excitation, seizures

Decreased effect with beta-blockers

Increased toxicity with other sympathomimetics (eg, epinephrine)

Do not use if solution is discolored or a precipitation is present; compatible with sterile water, 0.45% sodium chloride, and 0.9% sodium chloride; protect from light

Relaxes bronchial smooth muscle by action on beta₂-receptors with very little effect on heart rate

Peak effect: Inhaler: Within 5-15 minutes

Duration: 1-4 hours

Metabolism: In many tissues including the liver and lungs

Elimination: Renal, primarily (90%) as metabolites

Treatments are not usually repeated more than every 4 hours, except in severe cases

Inhalation: Oral: Adults: 1-2 inhalations every 4 hours as needed

Administer around-the-clock to promote less variation in peak and trough serum levels

Heart rate, blood pressure, respiratory rate

potassium (S)

Isoetharine is selective for beta-adrenergic receptors and not alpha receptors; therefore, there is no precaution in the use of vasoconstrictor

Dry mouth in 1% to 10% of patients

Use as directed (see below). Do not use more often than recommended. Store solution away from light. You may experience nervousness, dizziness, or fatigue; use caution when driving or engaging in tasks requiring alertness until response to drug is known. Frequent small meals may reduce incidence of nausea or vomiting. Report unresolved/persistent GI upset, rapid heartbeat or palpitations, dizziness or fatigue, trembling, or difficulty breathing. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

Instruct patient on use of nebulizer

Monitor heart rate, blood pressure, lung sounds, respiratory rate

Aerosol, oral, as mesylate: 340 mcg/metered spray

Solution, inhalation, as hydrochloride: 0.062% (4 mL); 0.08% (3.5 mL); 0.1% (2.5 mL, 5 mL); 0.125% (4 mL); 0.167% (3 mL); 0.17% (3 mL); 0.2% (2.5 mL); 0.25% (2 mL, 3.5 mL); 0.5% (0.5 mL); 1% (0.5 mL, 0.25 mL, 10 mL, 14 mL, 30 mL)

Rachelefsky GS and Siegel SC, "Asthma in Infants and Children - Treatment of Childhood Asthma: Part 11," J Allergy Clin Immunol, 1985, 76(3):409-25.