Interactions with herbs
St. John's Wort
  Interactions with supplements
5-Hydroxytryptophan (5-HTP)
Brewer's Yeast
Vitamin B6 (Pyridoxine)
Look Up > Drugs > Isocarboxazid
Isocarboxazid
Pronunciation
U.S. Brand Names
Generic Available
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Adverse Reactions
Drug Interactions
Mechanism of Action
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Dosage Forms

Pronunciation
(eye soe kar BOKS a zid)

U.S. Brand Names
Marplan®

Generic Available

No


Pharmacological Index

Antidepressant, Monoamine Oxidase Inhibitor


Use

Symptomatic treatment of atypical, nonendogenous or neurotic depression


Pregnancy Risk Factor

C


Contraindications

Uncontrolled hypertension; hypersensitivity to isocarboxazid; pheochromocytoma; congestive heart failure; severe renal or hepatic impairment


Adverse Reactions

>10%:

Cardiovascular: Orthostatic hypotension

Central nervous system: Drowsiness

Endocrine & metabolic: Decreased sexual ability

Neuromuscular & skeletal: Weakness, trembling

Ocular: Blurred vision

1% to 10%:

Cardiovascular: Tachycardia, peripheral edema

Central nervous system: Nervousness, chills

Dermatologic: Xerostomia

Gastrointestinal: Diarrhea, anorexia, constipation

<1%:

Central nervous system: Parkinsonian syndrome

Hematologic: Leukopenia

Hepatic: Hepatitis


Drug Interactions

Decreased effect of antihypertensives

Increased toxicity with disulfiram (possible seizures), fluoxetine (and other serotonin active agents), TCAs (cardiovascular instability), meperidine (cardiovascular instability), phenothiazines (hyperpyretic crisis), levodopa, sympathomimetics (hyperpyretic crisis), barbiturates, rauwolfia alkaloids (eg, reserpine), dextroamphetamine (psychoses), foods containing tyramine


Mechanism of Action

Thought to act by increasing endogenous concentrations of epinephrine, norepinephrine, dopamine, and serotonin through inhibition of the enzyme (monoamine oxidase) responsible for the breakdown of these neurotransmitters


Usual Dosage

Adults: Oral: 10 mg 3 times/day; reduce to 10-20 mg/day in divided doses when condition improves


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

Attempts should be made to avoid use of vasoconstrictor due to possibility of hypertensive episodes with monoamine oxidase inhibitors


Dental Health: Effects on Dental Treatment

Orthostatic hypotension in >10% of patients; meperidine should be avoided as an analgesic due to toxic reactions with MAO inhibitors


Patient Information

Avoid tyramine-containing foods and drinks


Dosage Forms

Tablet: 10 mg


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