| Pronunciation |
 (HYE
droe kwin
one) |
 |
| U.S. Brand Names |
| Ambi® Skin Tone [OTC]; Eldopaque®[OTC]; Eldopaque Forte®; Eldoquin®[OTC]; Eldoquin® Forte®; Esoterica® Facial [OTC]; Esoterica® Regular [OTC]; Esoterica® Sensitive Skin Formula [OTC]; Esoterica® Sunscreen [OTC]; Melanex®; Porcelana®[OTC]; Porcelana® Sunscreen [OTC]; Solaquin®[OTC]; Solaquin Forte® |
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| Generic Available |
|
No |
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| Canadian Brand Names |
| Neostrata™ HQ; Ultraquin™ |
|
| Synonyms |
| Hydroquinol; Quinol |
|
| Pharmacological Index |
|
Depigmenting Agent |
|
| Use |
|
Gradual bleaching of hyperpigmented skin conditions |
|
| Pregnancy Risk Factor |
|
C |
|
| Contraindications |
|
Sunburn, depilatory usage, known hypersensitivity to hydroquinone |
|
| Warnings/Precautions |
|
Limit application to area no larger than face and neck or hands and arms |
|
| Adverse Reactions |
|
1% to 10%: Local: Irritation |
|
| Drug Interactions |
|
No data reported |
|
| Mechanism of Action |
|
Produces reversible depigmentation of the skin by suppression of melanocyte metabolic processes, in particular the inhibition of the enzymatic oxidation of tyrosine to DOPA (3,4-dihydroxyphenylalanine); sun exposure reverses this effect and will cause repigmentation. |
|
| Pharmacodynamics/Kinetics |
|
Onset and duration of depigmentation produced by hydroquinone varies among individuals |
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| Usual Dosage |
|
Children >12 years and Adults: Topical: Apply thin layer and rub in twice daily |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Patient Information |
|
Use exactly as directed; do not overuse. Therapeutic effect may take several weeks. Test response by applying to small area of unbroken skin and check in 24 hours; if irritation or blistering occurs do not use. Avoid contact with eyes. Do not apply to open wounds or weeping areas. Before using, wash and dry area gently. Apply a thin film to affected area and rub in gently. Avoid direct sunlight or use sunblock or protective clothing to prevent repigmentation. Report swelling, redness, rash, itching, signs of infection, worsening of condition, or lack of healing. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding. |
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| Nursing Implications |
|
Use sunscreens or clothing; do not use on irritated or denuded skin; stop using if rash or irritation develops; for external use only, avoid eye contact |
|
| Dosage Forms |
|
Cream, topical: Esoterica® Sensitive Skin Formula: 1.5% (85 g) Eldopaque®, Eldoquin®, Esoterica® Facial, Esoterica® Regular, Porcelana®: 2% (14.2 g, 28.4 g, 60 g, 85 g, 120 g) Eldopaque Forte®, Eldoquin® Forte®, Melquin HP®: 4% (14.2 g, 28.4 g) Cream, topical, with sunscreen: Esoterica® Sunscreen, Porcelana®, Solaquin®: 2% (28.4 g, 120 g) Melpaque HP®, Nuquin HP®, Solaquin Forte®: 4% (14.2 g, 28.4 g) Gel, topical, with sunscreen (Solaquin Forte®): 4% (14.2 g, 28.4 g) Solution, topical (Melanex®): 3% (30 mL) |
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