Yes

Antitussive

Symptomatic relief of cough

C-III

C

Increased intracranial pressure, narrow-angle glaucoma, depressed ventilation, hypersensitivity to hydrocodone, homatropine, or any component

Use with caution in patients with hypersensitivity to other phenanthrene derivatives; use with caution in patients with respiratory diseases, or severe liver or renal failure; use with caution in children with spastic paralysis, in the elderly, and in patients with prostatic hypertrophy

>10%:

Cardiovascular: Hypotension

Central nervous system: Lightheadedness, dizziness, sedation, drowsiness, fatigue

Neuromuscular & skeletal: Weakness

1% to 10%:

Cardiovascular: Bradycardia, tachycardia

Central nervous system: Confusion

Gastrointestinal: Nausea, vomiting

Genitourinary: Decreased urination

Respiratory: Shortness of breath, dyspnea

<1%: Hallucinations, hypertension, dry hot skin, xerostomia, anorexia, impaired GI motility, biliary tract spasm, urinary tract spasm, diplopia, miosis, mydriasis, blurred vision, histamine release, physical and psychological dependence with prolonged use

Symptoms of overdose include CNS and respiratory depression; gastrointestinal cramping; dilated, unreactive pupils; blurred vision; hot, dry flushed skin; dryness of mucous membranes; difficulty in swallowing, foul breath, diminished or absent bowel sounds, urinary retention, tachycardia, hyperthermia, hypertension, increased respiratory rate

CNS depression is an extension of pharmacologic effect; treatment is supportive; naloxone 0.4 mg I.V. (0.01 mg/kg for children) with repeat administrations as necessary; anticholinergic toxicity is caused by strong binding of the drug to cholinergic receptors. For anticholinergic overdose with severe life-threatening symptoms, physostigmine 1-2 mg (0.5 or 0.02 mg/kg for children) S.C. or I.V., slowly may be given to reverse these effects.

Duration: Hydrocodone: 4-6 hours

Oral (based on hydrocodone component):

A single dose should not exceed 1.25 mg in children <2 years of age, 5 mg in children 2-12 years, and 10 mg in children >12 years

Adults: 5-10 mg every 4-6 hours, a single dose should not exceed 15 mg; do not administer more frequently than every 4 hours

Alcohol: Additive CNS effect, avoid use

ALT, AST (S)

No information available to require special precautions

Dry mouth

Take only as prescribed; do not exceed prescribed dose or frequency. May be habit-forming. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Avoid use of other depressants, alcohol, or sleep-inducing medications, or tranquilizers or pain medications unless approved by prescriber. You may experience orthostatic hypotension (change position slowly when rising from sitting or lying or when climbing stairs); drowsiness, impaired coordination, or blurred vision (use caution when driving or engaging in tasks requiring alertness until response to drug is known); nausea or vomiting (frequent small meals, frequent mouth care, chewing gum, or sucking hard candy may help); or constipation (increased exercise, fluids, or dietary fruit and fiber may help). Report persistent CNS changes (dizziness, sedation, tremor, or agitation), difficulty breathing, persistent abdominal cramping, visual changes, or lack of improvement or worsening or condition. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant; contraceptives may be recommended. Do not breast-feed.

Dispense in light-resistant container; observe patient for excessive sedation, respiratory depression, implement safety measures, assist with ambulation

Syrup (Hycodan®, Hydromet®): Hydrocodone bitartrate 5 mg and homatropine methylbromide 1.5 mg per 5 mL (120 mL, 480 mL, 4000 mL)

Tablet (Hycodan®, Oncet®, Tussigon®): Hydrocodone bitartrate 5 mg and homatropine methylbromide 1.5 mg