Yes

Antitussive/Expectorant

Symptomatic relief of nonproductive coughs associated with upper and lower respiratory tract congestion

C-III

C

Hypersensitivity to hydrocodone, guaifenesin, or any component; increased intracranial pressure; depressed ventilation

Can produce drug dependence and therefore has potential for abuse. Patients with chronic obstructive pulmonary disease.

Cardiovascular: Hypertension, postural hypotension, palpitations

Central nervous system: Drowsiness, sedation, mental clouding, mental and physical impairment, anxiety, fear, dysphoria, dizziness, psychotic dependence, mood changes

Gastrointestinal: Nausea, vomiting, constipation with prolonged use

Genitourinary: Ureteral spasm, urinary retention

Ocular: Blurred vision

Respiratory: Respiratory depression (dose related)

Symptoms of overdose include respiratory depression, Cheyne-Stokes respiration and cyanosis, extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold clammy skin, sometimes bradycardia and hypotension. Naloxone, 2 mg I.V. with repeat administration as necessary up to a total of 10 mg, can also be used to reverse toxic effects of the opiate.

Duration: Hydrocodone: 4-6 hours

Oral:

<2 years: 0.3 mg/kg/day (hydrocodone) in 4 divided doses

2-12 years: 2.5 mL every 4 hours, after meals and at bedtime

>12 years: 5 mL every 4 hours, after meals and at bedtime

Adults: 5 mL every 4 hours, after meals and at bedtime, not to exceed 30 mL in a 24-hour period

Should be administered after meals

No information available to require special precautions

No effects or complications reported

Take only as prescribed; do not exceed prescribed dose or frequency. May be habit-forming. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Avoid use of other depressants, alcohol, or sleep-inducing medications, or tranquilizers or pain medications unless approved by prescriber. You may experience orthostatic hypotension (change position slowly when rising from sitting or lying or when climbing stairs); drowsiness, impaired coordination, or blurred vision (use caution when driving or engaging in tasks requiring alertness until response to drug is known); nausea or vomiting (frequent small meals, frequent mouth care, chewing gum, or sucking hard candy may help); or constipation (increased exercise, fluids, or dietary fruit and fiber may help). Report persistent CNS changes (dizziness, sedation, tremor, or agitation), difficulty breathing, persistent abdominal cramping, visual changes, or lack of improvement or worsening or condition. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Do not breast-feed.

Liquid: Hydrocodone bitartrate 5 mg and guaifenesin 100 mg per 5 mL (120 mL, 480 mL)