Yes

Antitussive/Decongestant/Expectorant

Symptomatic relief of irritating, nonproductive cough associated with respiratory conditions such as bronchitis, bronchial asthma, tracheobronchitis, and the common cold

C-III

C

Hypersensitivity to any ingredient or component; severe hypertension; severe coronary artery disease; concurrent use with MAO inhibitors

May be habit-forming. Prescribe and administer the same degree of caution as all oral medications containing narcotics. Use caution in patients with hypertension, diabetes, ischemic heart disease, hyperthyroidism, increased intraocular pressure, prostatic hypertrophy. Patients with severe respiratory impairment or patients with impaired respiratory drive.

Incidence unknown:

Central nervous system: Drowsiness, fear, anxiety, tenseness, restlessness, pallor, insomnia, hallucinations, CNS depression

Gastrointestinal: GI upset, nausea, constipation with prolonged use

Genitourinary: Dysuria

Hepatic: Slight elevation in serum transaminase levels

Neuromuscular & skeletal: Weakness, tremor

Respiratory: Respiratory difficulty

Patients hyper-reactive to pseudoephedrine may display ephedrine-like reactions such as tachycardia, palpitations, headache, dizziness, or nausea; patient idiosyncrasy to adrenergic agents may be manifested by insomnia, dizziness, weakness, tremor, or arrhythmias.

Overdosage in the elderly may cause hallucinations, convulsions, CNS depression, or death. Naloxone, 2 mg I.V. with repeat administration as necessary up to a total of 10 mg, can also be used to reverse toxic effects of the opiate.

Duration: Hydrocodone: 4-6 hours

Adults: Oral: 5 mL every 4-6 hours

Use with caution since pseudoephedrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response

Guaifenesin: No effects or complications reported

Pseudoephedrine: Up to 10% of patients could experience tachycardia, palpitations, and dry mouth; use vasoconstrictor with caution

Take only as prescribed; do not exceed prescribed dose or frequency. May be habit-forming. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Avoid use of other depressants, alcohol, or sleep-inducing medications, or tranquilizers or pain medications unless approved by prescriber. You may experience orthostatic hypotension (change position slowly when rising from sitting or lying or climbing stairs); drowsiness, impaired coordination, or blurred vision (use caution when driving or engaging in tasks requiring alertness until response to drug is known); nausea or vomiting (frequent small meals, frequent mouth care, chewing gum, or sucking hard candy may help); constipation (increased exercise, fluids, or dietary fruit and fiber may help). Report persistent CNS changes (dizziness, sedation, tremor, or agitation), difficulty breathing, persistent abdominal cramping, visual changes, or lack of improvement or worsening or condition. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Do not breast-feed.

Liquid: Hydrocodone bitartrate 2.5 mg, pseudoephedrine hydrochloride 15 mg, and guaifenesin 100 mg per 5 mL (25 mL, 473 mL)

Liquid: Hydrocodone bitartrate 5 mg, pseudoephedrine hydrochloride 60 mg, and guaifenesin 200 mg per 5 mL with alcohol 12.5% (480 mL)