Yes

Antihypertensive Agent, Combination

Management of mild to moderate hypertension; treatment of edema in congestive heart failure and nephrotic syndrome, and cirrhosis of the liver accompanied by edema and/or ascites

C

Anuria, hyperkalemia, renal or hepatic failure, hypersensitivity to hydrochlorothiazide, spironolactone, or any component

1% to 10%:

Dermatology: Rash

Endocrine & metabolic: Hyperkalemia, gynecomastia, hyperchloremic metabolic acidosis (in decompensated hepatic cirrhosis), dehydration, hyponatremia

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea

Oral:

Adults: 1-8 tablets in 1-2 divided doses

Food with high potassium content, natural licorice, and salt substitutes should be avoided

Combination therapy for the treatment of hypertension should be individualized for each patient. Potential advantages for hydrochlorothiazide and spironolactone combination therapy may include improved compliance and synergistic reductions in blood pressure with an accompanied reduction in side effects (eg, hypokalemia). Thiazide and spironolactone also are effective in the management of heart failure.

No information available to require special precautions

No effects or complications reported

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to get pregnant. Consult prescriber if breast-feeding.

May interfere with digoxin serum assays

Monitor blood pressure, serum electrolytes, renal function

Tablet:

50/50: Hydrochlorothiazide 50 mg and spironolactone 50 mg