Hydralazine and Hydrochlorothiazide

Interactions with supplements

Vitamin B6 (Pyridoxine)

Zinc

Look Up > Drugs > Hydralazine and Hydrochlorothiazide

	Pronunciation
	U.S. Brand Names
	Generic Available
	Synonyms
	Pharmacological Index
	Use
	Pregnancy Risk Factor

	Usual Dosage
	Cardiovascular Considerations
	Dental Health: Local Anesthetic/Vasoconstrictor Precautions
	Dental Health: Effects on Dental Treatment
	Patient Information
	Dosage Forms

Pronunciation

(hye DRAL a zeen & hye droe klor oh THYE a zide)

U.S. Brand Names

Apresazide®

Generic Available

Yes

Synonyms

Hydrochlorothiazide and Hydralazine

Pharmacological Index

Antihypertensive Agent, Combination

Use

Management of moderate to severe hypertension and treatment of congestive heart failure

Pregnancy Risk Factor

Usual Dosage

Adults: Oral: 1 capsule twice daily

Cardiovascular Considerations

Combination therapy for the treatment of hypertension should be individualized for each patient. Potential advantages for hydralazine and hydrochlorothiazide combination therapy may include improved compliance and synergistic reductions in blood pressure with an accompanied reduction in side effects. Thiazide therapy improves cardiovascular outcomes in patients with hypertension. Hydralazine, in combination with isosorbide dinitrate, and hydrochlorothiazide are also used in management of heart failure.

Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions

Dental Health: Effects on Dental Treatment

No effects or complications reported

Patient Information

See individual agents. Pregnancy precautions: Inform prescriber if you are or intend to get pregnant.

Dosage Forms

Capsule:

50/50: Hydralazine hydrochloride 50 mg and hydrochlorothiazide 50 mg

100/50: Hydralazine hydrochloride 100 mg and hydrochlorothiazide 50 mg