Yes

Antibacterial, Topical

Surgical scrub and as a bacteriostatic skin cleanser; control an outbreak of gram-positive infection when other procedures have been unsuccessful

C

Known hypersensitivity to halogenated phenol derivatives or hexachlorophene; use in premature infants; use on burned or denuded skin; occlusive dressing; application to mucous membranes

Discontinue use if signs of cerebral irritability occur; exposure of preterm infants or patients with extensive burns has been associated with apnea, convulsions, agitation and coma; do not use for bathing infants, premature infants are particularly susceptible to hexachlorophene topical absorption

<1%: CNS injury, seizures, irritability, photosensitivity, dermatitis, redness, dry skin

Symptoms of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, seizures, hypotension, shock

Treatment is supportive

No data reported

Store in nonmetallic container ( incompatible with many metals); prolonged direct exposure to strong light may cause brownish surface discoloration, but this does not affect its action

Bacteriostatic polychlorinated biphenyl which inhibits membrane-bound enzymes and disrupts the cell membrane

Absorption: Percutaneously through inflamed, excoriated, and intact skin

Distribution: Crosses the placenta

Half-life: Infants: 6.1-44.2 hours

Children and Adults: Topical: Apply 5 mL cleanser and water to area to be cleansed; lather and rinse thoroughly under running water

No information available to require special precautions

No effects or complications reported

Do not leave on skin for prolonged contact; for external use only; discontinue product if condition persists or worsens and call physician; if suds enter eye, rinse out thoroughly with water

Do not use for bathing infants; premature infants are particularly susceptible to hexachlorophene topical absorption

Foam (Septisol®): 0.23% with alcohol 56% (180 mL, 600 mL)

Liquid, topical (pHisoHex®): 3% (8 mL, 150 mL, 500 mL, 3840 mL)

Halling H, "Suspected Link Between Exposure to Hexachlorophene and Malformed Infants," Ann N Y Acad Sci, 1979, 320:426-35.

Lester RS, "Topical Formulary for the Pediatrician," Pediatr Clin North Am, 1983, 30(4):749-65.

Lockhart JD, "How Toxic is Hexachlorophene?" Pediatrics, 1972, 50(2):229-35.

Marquardt ED, "Hexachlorophene Toxicity in a Pediatric Burn Patient," Drug Intell Clin Pharm, 1986, 20(7-8):624.

Nagy L and Orosz M, "Occupational Asthma Due to Hexachlorophene," Thorax, 1984, 39(8):630-1.